Suzee E Lee1. 1. Memory and Aging Center, University of California, San Francisco, Department of Neurology, San Francisco, California 94143, USA. suzeelee@memory.ucsf.edu
Abstract
PURPOSE OF REVIEW: This review covers the amyotrophic lateral sclerosis (ALS)/parkinsonism dementia complex (PDC) of Guam. Clinical and epidemiological characteristics, genetic possible and environmental causes, and neuropathological features of the disease are discussed. RECENT FINDINGS: Recent studies of clinical syndromes and neuropathological studies are compared with previous descriptions of the disease. The latest genetic and environmental studies are also reviewed. SUMMARY: In recent years, understanding of the molecular pathogenesis of neurodegenerative diseases has evolved. ALS/PDC shares neuropathological features found in many neurodegenerative diseases such as Alzheimer's disease, Lewy body disease, and frontotemporal lobar degeneration. Thus, examining ALS/PDC may provide further explanations on how various proteins seen in neurodegenerative disorders may be interrelated.
PURPOSE OF REVIEW: This review covers the amyotrophic lateral sclerosis (ALS)/parkinsonism dementia complex (PDC) of Guam. Clinical and epidemiological characteristics, genetic possible and environmental causes, and neuropathological features of the disease are discussed. RECENT FINDINGS: Recent studies of clinical syndromes and neuropathological studies are compared with previous descriptions of the disease. The latest genetic and environmental studies are also reviewed. SUMMARY: In recent years, understanding of the molecular pathogenesis of neurodegenerative diseases has evolved. ALS/PDC shares neuropathological features found in many neurodegenerative diseases such as Alzheimer's disease, Lewy body disease, and frontotemporal lobar degeneration. Thus, examining ALS/PDC may provide further explanations on how various proteins seen in neurodegenerative disorders may be interrelated.
Authors: Manuel Menéndez-González; Tania Álvarez-Avellón; José M Salas-Pacheco; Benito de Celis-Alonso; Kathryn A Wyman-Chick; Oscar Arias-Carrión Journal: Front Neurol Date: 2018-05-24 Impact factor: 4.003