BACKGROUND: Endothelial dysfunction is present in established rheumatoid arthritis, but it is not clear at what stage of the disease this abnormality develops. We set out to determine whether endothelial damage/dysfunction is present in a group of patients with early arthritis (EA) (new onset inflammatory arthritis, EA). MATERIALS AND METHODS: Eighteen patients with EA, 48 healthy controls and 25 disease controls were recruited. Plasma was obtained for endothelial [von Willebrand factor (vWF) and soluble E-selectin] and angiogenesis markers (vascular endothelial growth factor and its receptor sFlt-1), adhesion molecules (intercellular adhesion molecule 1 and vascular cell adhesion molecule 1) and circulating endothelial cells (CECs, as a marker of endothelial damage). Microvascular endothelial function was assessed using laser Doppler perfusion imaging and macrovascular function using flow-mediated dilatation of the brachial artery. RESULTS: von Willebrand factor and CECs (both P < 0.05) were significantly elevated in EA suggesting endothelial dysfunction and damage but were unrelated to classical laboratory markers of inflammation C-reactive protein, erythrocyte sedimentation rate or IL6. No other biomarkers was elevated in EA. Microvascular and macrovascular abnormalities were confined to endothelium-independent (smooth muscle cell) responses. CONCLUSIONS: Endothelial damage/dysfunction is present early in the course of inflammatory arthritis but is not directly related to inflammation markers.
BACKGROUND: Endothelial dysfunction is present in established rheumatoid arthritis, but it is not clear at what stage of the disease this abnormality develops. We set out to determine whether endothelial damage/dysfunction is present in a group of patients with early arthritis (EA) (new onset inflammatory arthritis, EA). MATERIALS AND METHODS: Eighteen patients with EA, 48 healthy controls and 25 disease controls were recruited. Plasma was obtained for endothelial [von Willebrand factor (vWF) and soluble E-selectin] and angiogenesis markers (vascular endothelial growth factor and its receptor sFlt-1), adhesion molecules (intercellular adhesion molecule 1 and vascular cell adhesion molecule 1) and circulating endothelial cells (CECs, as a marker of endothelial damage). Microvascular endothelial function was assessed using laser Doppler perfusion imaging and macrovascular function using flow-mediated dilatation of the brachial artery. RESULTS:von Willebrand factor and CECs (both P < 0.05) were significantly elevated in EA suggesting endothelial dysfunction and damage but were unrelated to classical laboratory markers of inflammationC-reactive protein, erythrocyte sedimentation rate or IL6. No other biomarkers was elevated in EA. Microvascular and macrovascular abnormalities were confined to endothelium-independent (smooth muscle cell) responses. CONCLUSIONS: Endothelial damage/dysfunction is present early in the course of inflammatory arthritis but is not directly related to inflammation markers.
Authors: László Dávida; Vanda Pongrácz; Emir Awad Mohamed; Szilvia Szamosi; Gabriella Szücs; Andrea Váncsa; Orsolya Tímár; Zoltán Csiki; Edit Végh; Pál Soltész; Zoltán Szekanecz; György Kerekes Journal: Rheumatol Int Date: 2019-12-19 Impact factor: 2.631
Authors: Gönül Gurol; Ihsan Hakkı Ciftci; Halil Harman; Engin Karakece; Ayhan Kamanli; Ibrahim Tekeoglu Journal: Int J Clin Exp Pathol Date: 2015-02-01
Authors: G Palma Zochio Tozzato; E F Taipeiro; M A Spadella; P Marabini Filho; M R de Assis; C P Carlos; A P Girol; A B Chies Journal: Clin Exp Immunol Date: 2015-12-10 Impact factor: 4.330
Authors: S l Reynolds; A S Williams; H Williams; S Smale; H J Stephenson; N Amos; S J George; V B O'Donnell; D Lang Journal: Br J Pharmacol Date: 2012-10 Impact factor: 8.739