Literature DB >> 21983564

Misfolded proteins driven to destruction by Hul5.

Daniel Finley.   

Abstract

Misfolded proteins are potentially toxic and are therefore subjected to highly selective degradation by the ubiquitin-proteasome system. The identification of the Hul5 ubiquitin ligase as a major mediator of such 'quality-control' ubiquitylation following heat shock raises new questions about the design of these pathways.

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Year:  2011        PMID： 21983564     DOI： 10.1038/ncb2371

Source DB:  PubMed          Journal:  Nat Cell Biol        ISSN： 1465-7392            Impact factor:   28.824


  18 in total

1.  A novel ubiquitination factor, E4, is involved in multiubiquitin chain assembly.

Authors:  M Koegl; T Hoppe; S Schlenker; H D Ulrich; T U Mayer; S Jentsch
Journal:  Cell       Date:  1999-03-05       Impact factor: 41.582

2.  Misfolded proteins impose a dosage-dependent fitness cost and trigger a cytosolic unfolded protein response in yeast.

Authors:  Kerry A Geiler-Samerotte; Michael F Dion; Bogdan A Budnik; Stephanie M Wang; Daniel L Hartl; D Allan Drummond
Journal:  Proc Natl Acad Sci U S A       Date:  2010-12-27       Impact factor: 11.205

3.  Mass spectrometric characterization of the affinity-purified human 26S proteasome complex.

Authors:  Xiaorong Wang; Chi-Fen Chen; Peter R Baker; Phang-lang Chen; Peter Kaiser; Lan Huang
Journal:  Biochemistry       Date:  2007-02-27       Impact factor: 3.162

4.  Degradation of misfolded protein in the cytoplasm is mediated by the ubiquitin ligase Ubr1.

Authors:  Frederik Eisele; Dieter H Wolf
Journal:  FEBS Lett       Date:  2008-11-27       Impact factor: 4.124

5.  Deubiquitinating enzyme Ubp6 functions noncatalytically to delay proteasomal degradation.

Authors:  John Hanna; Nathaniel A Hathaway; Yoshiko Tone; Bernat Crosas; Suzanne Elsasser; Donald S Kirkpatrick; David S Leggett; Steven P Gygi; Randall W King; Daniel Finley
Journal:  Cell       Date:  2006-10-06       Impact factor: 41.582

6.  Extensive immunoglobulin production sensitizes myeloma cells for proteasome inhibition.

Authors:  Silke Meister; Ulrich Schubert; Kirsten Neubert; Kai Herrmann; Renate Burger; Martin Gramatzki; Sabine Hahn; Sandra Schreiber; Sabine Wilhelm; Martin Herrmann; Hans-Martin Jäck; Reinhard E Voll
Journal:  Cancer Res       Date:  2007-02-15       Impact factor: 12.701

7.  Identification of aneuploidy-tolerating mutations.

Authors:  Eduardo M Torres; Noah Dephoure; Amudha Panneerselvam; Cheryl M Tucker; Charles A Whittaker; Steven P Gygi; Maitreya J Dunham; Angelika Amon
Journal:  Cell       Date:  2010-09-16       Impact factor: 41.582

8.  Enhancement of proteasome activity by a small-molecule inhibitor of USP14.

Authors:  Byung-Hoon Lee; Min Jae Lee; Soyeon Park; Dong-Chan Oh; Suzanne Elsasser; Ping-Chung Chen; Carlos Gartner; Nevena Dimova; John Hanna; Steven P Gygi; Scott M Wilson; Randall W King; Daniel Finley
Journal:  Nature       Date:  2010-09-09       Impact factor: 49.962

9.  Hul5 HECT ubiquitin ligase plays a major role in the ubiquitylation and turnover of cytosolic misfolded proteins.

Authors:  Nancy N Fang; Alex H M Ng; Vivien Measday; Thibault Mayor
Journal:  Nat Cell Biol       Date:  2011-10-09       Impact factor: 28.824

10.  Depletion of 26S proteasomes in mouse brain neurons causes neurodegeneration and Lewy-like inclusions resembling human pale bodies.

Authors:  Lynn Bedford; David Hay; Anny Devoy; Simon Paine; Des G Powe; Rashmi Seth; Trevor Gray; Ian Topham; Kevin Fone; Nooshin Rezvani; Maureen Mee; Tim Soane; Robert Layfield; Paul W Sheppard; Ted Ebendal; Dmitry Usoskin; James Lowe; R John Mayer
Journal:  J Neurosci       Date:  2008-08-13       Impact factor: 6.167
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  9 in total

1.  Proteasome stress responses in Schistosoma mansoni.

Authors:  Renato Graciano de Paula; Alice Maria de Magalhães Ornelas; Enyara Rezende Morais; Matheus de Souza Gomes; Daniela de Paula Aguiar; Lizandra Guidi Magalhães; Vanderlei Rodrigues
Journal:  Parasitol Res       Date:  2015-02-10       Impact factor: 2.289

2.  The exocyst subunit Sec3 is regulated by a protein quality control pathway.

Authors:  Caroline Kampmeyer; Antonina Karakostova; Signe M Schenstrøm; Amanda B Abildgaard; Anne-Marie Lauridsen; Isabelle Jourdain; Rasmus Hartmann-Petersen
Journal:  J Biol Chem       Date:  2017-08-01       Impact factor: 5.157

Review 3.  Ribosome-associated quality-control mechanisms from bacteria to humans.

Authors:  Sebastian Filbeck; Federico Cerullo; Stefan Pfeffer; Claudio A P Joazeiro
Journal:  Mol Cell       Date:  2022-04-21       Impact factor: 19.328

Review 4.  Viewing Extrinsic Proteotoxic Stress Through the Lens of Amyloid Cardiomyopathy.

Authors:  Valerie Sapp; Mohit Jain; Ronglih Liao
Journal:  Physiology (Bethesda)       Date:  2016-07

5.  Convergence of mammalian RQC and C-end rule proteolytic pathways via alanine tailing.

Authors:  Anna Thrun; Aitor Garzia; Yu Kigoshi-Tansho; Pratik R Patil; Charles S Umbaugh; Teresa Dallinger; Jia Liu; Sylvia Kreger; Annarita Patrizi; Gregory A Cox; Thomas Tuschl; Claudio A P Joazeiro
Journal:  Mol Cell       Date:  2021-04-27       Impact factor: 17.970

Review 6.  Repair or destruction-an intimate liaison between ubiquitin ligases and molecular chaperones in proteostasis.

Authors:  Éva Kevei; Wojciech Pokrzywa; Thorsten Hoppe
Journal:  FEBS Lett       Date:  2017-07-24       Impact factor: 4.124

Review 7.  Protein quality control in the nucleus.

Authors:  Sofie V Nielsen; Esben G Poulsen; Caio A Rebula; Rasmus Hartmann-Petersen
Journal:  Biomolecules       Date:  2014-07-09

8.  Ubiquitin orchestrates proteasome dynamics between proliferation and quiescence in yeast.

Authors:  Zhu Chao Gu; Edwin Wu; Carolin Sailer; Julia Jando; Erin Styles; Ina Eisenkolb; Maike Kuschel; Katharina Bitschar; Xiaorong Wang; Lan Huang; Adriano Vissa; Christopher M Yip; Ravikiran S Yedidi; Helena Friesen; Cordula Enenkel
Journal:  Mol Biol Cell       Date:  2017-08-02       Impact factor: 4.138

9.  Genetic Selection Based on a Ste6*C-HA-Ura3 Substrate Identifies New Cytosolic Quality Control Alleles in Saccharomyces cerevisiae.

Authors:  Shu Ning Chan; Rupali Prasad; Paul Matsudaira
Journal:  G3 (Bethesda)       Date:  2020-06-01       Impact factor: 3.154
  9 in total

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