Literature DB >> 21982701

Estrogens and obesity: is it all in our heads?

Sarah Hart-Unger1, Kenneth S Korach.   

Abstract

Estrogens have preventative effects on weight gain and associated comorbidities, but the tissue-specific targets remain unknown. Here, Xu et al. (2011) demonstrate that ablation of estrogen signaling in two populations of hypothalamic neurons leads to weight gain and subsequent metabolic dysregulation and could be important target sites of estrogen actions.

Entities:  

Year:  2011        PMID： 21982701      PMCID： PMC4166555          DOI： 10.1016/j.cmet.2011.09.003

Source DB:  PubMed          Journal:  Cell Metab        ISSN： 1550-4131            Impact factor:   27.287


  9 in total

1.  PI3K signaling in the ventromedial hypothalamic nucleus is required for normal energy homeostasis.

Authors:  Yong Xu; Jennifer W Hill; Makoto Fukuda; Laurent Gautron; Jong-Woo Sohn; Ki-Woo Kim; Charlotte E Lee; Michelle J Choi; Danielle A Lauzon; Harveen Dhillon; Bradford B Lowell; Jeffrey M Zigman; Jean J Zhao; Joel K Elmquist
Journal:  Cell Metab       Date:  2010-07-07       Impact factor: 27.287

2.  Distinct hypothalamic neurons mediate estrogenic effects on energy homeostasis and reproduction.

Authors:  Yong Xu; Thekkethil P Nedungadi; Liangru Zhu; Nasim Sobhani; Boman G Irani; Kathryn E Davis; Xiaorui Zhang; Fang Zou; Lana M Gent; Lisa D Hahner; Sohaib A Khan; Carol F Elias; Joel K Elmquist; Deborah J Clegg
Journal:  Cell Metab       Date:  2011-10-05       Impact factor: 27.287

3.  Myeloid-specific estrogen receptor alpha deficiency impairs metabolic homeostasis and accelerates atherosclerotic lesion development.

Authors:  Vicent Ribas; Brian G Drew; Jamie A Le; Teo Soleymani; Pedram Daraei; Daniel Sitz; Laila Mohammad; Darren C Henstridge; Mark A Febbraio; Sylvia C Hewitt; Kenneth S Korach; Steven J Bensinger; Andrea L Hevener
Journal:  Proc Natl Acad Sci U S A       Date:  2011-09-07       Impact factor: 11.205

4.  Genetic rescue of nonclassical ERα signaling normalizes energy balance in obese Erα-null mutant mice.

Authors:  Cheryl J Park; Zhen Zhao; Christine Glidewell-Kenney; Milos Lazic; Pierre Chambon; Andrée Krust; Jeffrey Weiss; Deborah J Clegg; Andrea Dunaif; J Larry Jameson; Jon E Levine
Journal:  J Clin Invest       Date:  2011-01-18       Impact factor: 14.808

5.  Clinical spectrum of obesity and mutations in the melanocortin 4 receptor gene.

Authors:  I Sadaf Farooqi; Julia M Keogh; Giles S H Yeo; Emma J Lank; Tim Cheetham; Stephen O'Rahilly
Journal:  N Engl J Med       Date:  2003-03-20       Impact factor: 91.245

6.  Estrogen resistance caused by a mutation in the estrogen-receptor gene in a man.

Authors:  E P Smith; J Boyd; G R Frank; H Takahashi; R M Cohen; B Specker; T C Williams; D B Lubahn; K S Korach
Journal:  N Engl J Med       Date:  1994-10-20       Impact factor: 91.245

7.  Impaired oxidative metabolism and inflammation are associated with insulin resistance in ERalpha-deficient mice.

Authors:  Vicent Ribas; M T Audrey Nguyen; Darren C Henstridge; Anh-Khoi Nguyen; Simon W Beaven; Matthew J Watt; Andrea L Hevener
Journal:  Am J Physiol Endocrinol Metab       Date:  2009-11-17       Impact factor: 4.310

Review 8.  The emergence of the metabolic syndrome with menopause.

Authors:  Molly C Carr
Journal:  J Clin Endocrinol Metab       Date:  2003-06       Impact factor: 5.958

9.  Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results From the Women's Health Initiative randomized controlled trial.

Authors:  Jacques E Rossouw; Garnet L Anderson; Ross L Prentice; Andrea Z LaCroix; Charles Kooperberg; Marcia L Stefanick; Rebecca D Jackson; Shirley A A Beresford; Barbara V Howard; Karen C Johnson; Jane Morley Kotchen; Judith Ockene
Journal:  JAMA       Date:  2002-07-17       Impact factor: 56.272
  9 in total
  8 in total

1.  A Prospective Investigation of the Association Between Urinary Excretion of Dietary Lignan Metabolites and Weight Change in US Women.

Authors:  Yang Hu; Yan Song; Adrian A Franke; Frank B Hu; Rob M van Dam; Qi Sun
Journal:  Am J Epidemiol       Date:  2015-08-18       Impact factor: 4.897

2.  Long-term supplementation of dehydroepiandrosterone improved depressive-like behaviors by increasing BDNF expression in the hippocampus in ovariectomized rats.

Authors:  Siyang Wu; Mei Ye; Zhulin Li; Shizhong Bu; Yisheng Zhang
Journal:  Heliyon       Date:  2020-10-08

Review 3.  The role of hypothalamic estrogen receptors in metabolic regulation.

Authors:  Aaron Frank; Lynda M Brown; Deborah J Clegg
Journal:  Front Neuroendocrinol       Date:  2014-05-29       Impact factor: 8.606

Review 4.  Minireview: the year in review of estrogen regulation of metabolism.

Authors:  Deborah J Clegg
Journal:  Mol Endocrinol       Date:  2012-10-09

5.  Sequential Exposure to Obesogenic Factors in Females Rats: From Physiological Changes to Lipid Metabolism in Liver and Mesenteric Adipose Tissue.

Authors:  Marta G Novelle; María J Vázquez; Juan R Peinado; Kátia D Martinello; Miguel López; Simon M Luckman; Manuel Tena-Sempere; María M Malagón; Rubén Nogueiras; Carlos Diéguez
Journal:  Sci Rep       Date:  2017-04-07       Impact factor: 4.379

Review 6.  Estrogen Deficiency and the Origin of Obesity during Menopause.

Authors:  Fernando Lizcano; Guillermo Guzmán
Journal:  Biomed Res Int       Date:  2014-03-06       Impact factor: 3.411

7.  Hawthorn Fruit Extract Elevates Expression of Nrf2/HO-1 and Improves Lipid Profiles in Ovariectomized Rats.

Authors:  Jeong-Hyun Yoo; Yanan Liu; Hyun-Sook Kim
Journal:  Nutrients       Date:  2016-05-13       Impact factor: 5.717

Review 8.  Metabolism Disrupting Chemicals and Alteration of Neuroendocrine Circuits Controlling Food Intake and Energy Metabolism.

Authors:  Marilena Marraudino; Brigitta Bonaldo; Alice Farinetti; GianCarlo Panzica; Giovanna Ponti; Stefano Gotti
Journal:  Front Endocrinol (Lausanne)       Date:  2019-01-09       Impact factor: 5.555
  8 in total

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