PURPOSE: To report spontaneous corneal clearing with improved visual acuity and central endothelial cell repopulation after Descemet's stripping without endothelial replacement. DESIGN: Interventional case report. METHODS: A 34-year-old woman with bilateral decreased vision secondary to corneal edema from endothelial dysfunction underwent Descemet's stripping endothelial keratoplasty (DSEK) in the right eye and Descemet's stripping only in the left eye. Histopathologic evaluation confirmed a dual diagnosis of Fuchs' endothelial dystrophy and posterior polymorphous membrane dystrophy from Descemet's membrane specimens removed from each eye. After primary graft failure with regraft in the right eye, the second posterior corneal lenticule detached and was removed and not replaced. The cornea cleared, and central endothelial cell repopulation was documented by confocal microscopy. Therefore, Descemet's stripping without endothelial replacement was performed in the left eye. The left cornea also cleared with central endothelial cell repopulation. MAIN OUTCOME MEASURES: Postoperative visual acuity and central endothelial cell repopulation. RESULTS: Endothelial migration after Descemet's stripping alone in the left eye, with probable host endothelial cell repopulation in the right eye. CONCLUSIONS: Endothelial cell migration after Descemet's stripping procedure without insertion of endothelial graft can occur, resulting from host endothelial cell repopulation with corneal clearing and improved visual acuity.
PURPOSE: To report spontaneous corneal clearing with improved visual acuity and central endothelial cell repopulation after Descemet's stripping without endothelial replacement. DESIGN: Interventional case report. METHODS: A 34-year-old woman with bilateral decreased vision secondary to corneal edema from endothelial dysfunction underwent Descemet's stripping endothelial keratoplasty (DSEK) in the right eye and Descemet's stripping only in the left eye. Histopathologic evaluation confirmed a dual diagnosis of Fuchs' endothelial dystrophy and posterior polymorphous membrane dystrophy from Descemet's membrane specimens removed from each eye. After primary graft failure with regraft in the right eye, the second posterior corneal lenticule detached and was removed and not replaced. The cornea cleared, and central endothelial cell repopulation was documented by confocal microscopy. Therefore, Descemet's stripping without endothelial replacement was performed in the left eye. The left cornea also cleared with central endothelial cell repopulation. MAIN OUTCOME MEASURES: Postoperative visual acuity and central endothelial cell repopulation. RESULTS: Endothelial migration after Descemet's stripping alone in the left eye, with probable host endothelial cell repopulation in the right eye. CONCLUSIONS: Endothelial cell migration after Descemet's stripping procedure without insertion of endothelial graft can occur, resulting from host endothelial cell repopulation with corneal clearing and improved visual acuity.
Authors: W Barry Lee; Deborah S Jacobs; David C Musch; Stephen C Kaufman; William J Reinhart; Roni M Shtein Journal: Ophthalmology Date: 2009-07-30 Impact factor: 12.079
Authors: S Biswas; F L Munier; J Yardley; N Hart-Holden; R Perveen; P Cousin; J E Sutphin; B Noble; M Batterbury; C Kielty; A Hackett; R Bonshek; A Ridgway; D McLeod; V C Sheffield; E M Stone; D F Schorderet; G C Black Journal: Hum Mol Genet Date: 2001-10-01 Impact factor: 6.150
Authors: Chandra Balachandran; Lisanne Ham; Christianne A Verschoor; T San Ong; Jacqueline van der Wees; Gerrit R J Melles Journal: Am J Ophthalmol Date: 2009-05-13 Impact factor: 5.258
Authors: Jodhbir S Mehta; Eranga N Vithana; Donald T H Tan; Victor H K Yong; Gary H F Yam; Ricky W K Law; Wesley G W Chong; Calvin P Pang; Tin Aung Journal: Invest Ophthalmol Vis Sci Date: 2008-01 Impact factor: 4.799
Authors: George D Kymionis; Dimitrios A Liakopoulos; Michael A Grentzelos; Irini Naoumidi; Georgios A Kontadakis; Konstantinos I Tsoulnaras; Myrsini K Petrelli Journal: Saudi J Ophthalmol Date: 2017-05-24
Authors: Stephan Ong Tone; Viridiana Kocaba; Myriam Böhm; Adam Wylegala; Tomas L White; Ula V Jurkunas Journal: Prog Retin Eye Res Date: 2020-05-08 Impact factor: 21.198