Literature DB >> 21980924

BDNF Val66Met and cognition: all, none, or some? A meta-analysis of the genetic association.

S D Mandelman1, E L Grigorenko.   

Abstract

The Val66Met, G196A (rs6265) polymorphism in the brain-derived neurotrophic factor gene, BDNF, located at 11p13, has been associated with a wide range of cognitive functions. Yet, the pattern of results is complex and conflicting. In this study, we conducted a meta-analysis that included 23 publications containing 31 independent samples comprised of 7095 individuals. The phenotypes that were examined in this analysis covered a wide variety of cognitive functions and included indicators of general cognitive ability, memory, executive function, visual processing skills and cognitive fluency. The meta-analysis did not establish significant genetic associations between the Val66Met polymorphism and any of the phenotypes that were included.
© 2011 The Authors. Genes, Brain and Behavior © 2011 Blackwell Publishing Ltd and International Behavioural and Neural Genetics Society.

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Year:  2011        PMID： 21980924      PMCID： PMC3268899          DOI： 10.1111/j.1601-183X.2011.00738.x

Source DB:  PubMed          Journal:  Genes Brain Behav        ISSN： 1601-183X            Impact factor:   3.449


  62 in total

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4.  Effect of the BDNF V166M polymorphism on working memory in healthy adolescents.

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8.  Brain-derived neurotrophic factor polymorphism Val66Met influences cognitive abilities in the elderly.

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  41 in total

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5.  Sex-dependent effect of the BDNF Val66Met polymorphism on executive functioning and processing speed in older adults: evidence from the health ABC study.

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7.  The brain-derived neurotrophic factor Val66Met polymorphism moderates an effect of physical activity on working memory performance.

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