OBJECTIVES: To examine the clinical factors associated with adenomas ≥6 mm presenting as non-polypoid polyps. METHODS: We conducted a prospective cross-sectional examination with a target population of consecutive asymptomatic patients presenting to a University endoscopy center for screening colonoscopy. Data, which included demographics, known colorectal cancer risk factors, and medications, were collected. One endoscopist using a high-definition wide-angle colonoscope performed all of the colonoscopies. Polyp morphology was classified according to the JRSC (Japanese Research Society for Cancer of Colon and Rectum) JRSC guidelines. RESULTS: A total of 600 patients were screened and 150 adenomas ≥6 mm were detected. Of these 150 adenomas, 70 adenomas had a non-polypoid morphology while 80 were polypoid. Adenomas were more likely to present as non-polypoid in women as compared with men (adjusted odds ratio (AOR)=2.49; 95% confidence interval (CI)=1.08-5.75, P=0.03). Location of the adenoma in the proximal colon (AOR=4.21; 95% CI=1.83-9.71, P=0.001) and smoking (AOR=2.54; 95% CI=1.01-6.38, P=0.048) were independent predictors of flat morphology. In addition, advanced adenomas were also more likely to be flat in women (AOR=7.99; 95% CI=1.32-48.39, P=0.02) and proximal location was an independent predictor of flat morphology. CONCLUSIONS: Adenomas ≥6 mm and advanced lesions were more likely to present as non-polypoid polyps in women when compared with men. Proximal location and smoking were also observed to be independent predictors of flat morphology.
OBJECTIVES: To examine the clinical factors associated with adenomas ≥6 mm presenting as non-polypoid polyps. METHODS: We conducted a prospective cross-sectional examination with a target population of consecutive asymptomatic patients presenting to a University endoscopy center for screening colonoscopy. Data, which included demographics, known colorectal cancer risk factors, and medications, were collected. One endoscopist using a high-definition wide-angle colonoscope performed all of the colonoscopies. Polyp morphology was classified according to the JRSC (Japanese Research Society for Cancer of Colon and Rectum) JRSC guidelines. RESULTS: A total of 600 patients were screened and 150 adenomas ≥6 mm were detected. Of these 150 adenomas, 70 adenomas had a non-polypoid morphology while 80 were polypoid. Adenomas were more likely to present as non-polypoid in women as compared with men (adjusted odds ratio (AOR)=2.49; 95% confidence interval (CI)=1.08-5.75, P=0.03). Location of the adenoma in the proximal colon (AOR=4.21; 95% CI=1.83-9.71, P=0.001) and smoking (AOR=2.54; 95% CI=1.01-6.38, P=0.048) were independent predictors of flat morphology. In addition, advanced adenomas were also more likely to be flat in women (AOR=7.99; 95% CI=1.32-48.39, P=0.02) and proximal location was an independent predictor of flat morphology. CONCLUSIONS:Adenomas ≥6 mm and advanced lesions were more likely to present as non-polypoid polyps in women when compared with men. Proximal location and smoking were also observed to be independent predictors of flat morphology.
Authors: Annalisa de Leone; Darina Tamayo; Giancarla Fiori; Davide Ravizza; Cristina Trovato; Giuseppe De Roberto; Linda Fazzini; Marco Dal Fante; Cristiano Crosta Journal: World J Gastrointest Endosc Date: 2013-09-16
Authors: Karl Mårild; Weimin Ye; Benjamin Lebwohl; Peter H R Green; Martin J Blaser; Tim Card; Jonas F Ludvigsson Journal: BMC Gastroenterol Date: 2013-07-08 Impact factor: 3.067
Authors: Su Young Kim; Hyun-Soo Kim; Yun Tae Kim; Jung Kuk Lee; Hong Jun Park; Hee Man Kim; Dae Ryoung Kang Journal: Clin Transl Gastroenterol Date: 2021-04-30 Impact factor: 4.396