Mechanically robust, cell encapsulating microdevices fabricated using photolithographic methods can lead to more efficient immunoisolation in comparison to cell encapsulating hydrogels. There is a need to develop adhesive bonding methods which can seal such microdevices under physiologically friendly conditions. We report the bonding of SU-8 based substrates through (i) magnetic self assembly, (ii) using medical grade photocured adhesive and (iii) moisture and photochemical cured polymerization. Magnetic self-assembly, carried out in biofriendly aqueous buffers, provides weak bonding not suitable for long term applications. Moisture cured bonding of covalently modified SU-8 substrates, based on silanol condensation, resulted in weak and inconsistent bonding. Photocured bonding using a medical grade adhesive and of acrylate modified substrates provided stable bonding. Of the methods evaluated, photocured adhesion provided the strongest and most stable adhesion.
Mechanically robust, cell encapsulating microdevices fabricated un class="Chemical">sing photolithographic methods can lead to more efficient immunoisolation in comparison to cell encapsulating hydrogels. There is a need to develop adhesive bonding methods which can seal such microdevices under physiologically friendly conditions. We report the bonding of SU-8 based substrates through (i) magnetic self assembly, (ii) using medical grade photocured adhesive and (iii) moisture and photochemical cured polymerization. Magnetic self-assembly, carried out in biofriendly aqueous buffers, provides weak bonding not suitable for long term applications. Moisture cured bonding of covalently modified SU-8 substrates, based on silanol condensation, resulted in weak and inconsistent bonding. Photocured bonding using a medical grade adhesive and of acrylate modified substrates provided stable bonding. Of the methods evaluated, photocured adhesion provided the strongest and most stable adhesion.
Authors: Geoffrey Kotzar; Mark Freas; Phillip Abel; Aaron Fleischman; Shuvo Roy; Christian Zorman; James M Moran; Jeff Melzak Journal: Biomaterials Date: 2002-07 Impact factor: 12.479
Authors: Barjor Gimi; Joonbum Kwon; Andrey Kuznetsov; Behroze Vachha; Richard L Magin; Louis H Philipson; Jeong-Bong Lee Journal: J Diabetes Sci Technol Date: 2009-03
Authors: Alexander G Zestos; Michael D Nguyen; Brian L Poe; Christopher B Jacobs; B Jill Venton Journal: Sens Actuators B Chem Date: 2013-03-27 Impact factor: 7.460
Authors: Krishnamurthy V Nemani; Karen L Moodie; Jeoffry B Brennick; Alison Su; Barjor Gimi Journal: Mater Sci Eng C Mater Biol Appl Date: 2013-07-12 Impact factor: 7.328