Literature DB >> 21967606

Role of corticotropin-releasing factor in the median raphe nucleus in yohimbine-induced reinstatement of alcohol seeking in rats.

A D Lê1, Douglas Funk, Kathleen Coen, Zhaoxia Li, Yavin Shaham.   

Abstract

The pharmacological stressor yohimbine increases ongoing alcohol self-administration and reinstates alcohol seeking in rats. This effect is attenuated by systemic injections of a corticotropin-releasing factor (CRF) antagonist. The brain sites involved in CRF's role in yohimbine-induced alcohol taking and seeking are unknown. We report that injections of the CRF receptor antagonist d-Phe CRF into the median raphe nucleus (MRN) attenuated yohimbine-induced reinstatement of alcohol seeking but had no effect on yohimbine-induced increases in alcohol intake during ongoing self-administration. Results indicate an important role of MRN CRF receptors in yohimbine-induced reinstatement of alcohol seeking but not yohimbine-induced increases in alcohol intake.
© 2011 The Authors, Addiction Biology © 2011 Society for the Study of Addiction.

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Year:  2011        PMID： 21967606      PMCID： PMC3288693          DOI： 10.1111/j.1369-1600.2011.00374.x

Source DB:  PubMed          Journal:  Addict Biol        ISSN： 1355-6215            Impact factor:   4.280


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