Literature DB >> 21966114

Potential Effect of Bacopa monnieri on Nitrobenzene Induced Liver Damage in Rats.

B Rajalakshmy Menon1, M A Rathi, L Thirumoorthi, V K Gopalakrishnan.   

Abstract

The study was designed to evaluate the hepatoprotective activity of ethanolic extract of Bacopa monnieri in acute experimental liver injury induced by Nitrobenzene in rats. The extract at the dose of 200 mg/kg body weight was administered orally once every day for 10 days. The increased serum marker enzymes, Aspartate transaminase, Alanine transaminase and alkaline phosphatase were restored towards normalization significantly by the extract. Significant increase in SOD, CAT and GPx was observed in extract treated liver injured experimental rats. Histopathological examination of the liver tissues supported the hepatoprotection. It is concluded that the ethanolic extract of Bacopa monieri plant possess good hepatoprotective activity.

Entities:  

Keywords:  Antioxidants; Hepatoprotective effect; Liver marker enzymes

Year:  2010        PMID： 21966114      PMCID： PMC2994561          DOI： 10.1007/s12291-010-0048-4

Source DB:  PubMed          Journal:  Indian J Clin Biochem        ISSN： 0970-1915


  14 in total

Review 1.  The need for establishing identities of 'bacoside A and B', the putative major bioactive saponins of Indian medicinal plant Bacopa monnieri.

Authors:  M Deepak; A Amit
Journal:  Phytomedicine       Date:  2004-02       Impact factor: 5.340

2.  Colorimetric assay of catalase.

Authors:  A K Sinha
Journal:  Anal Biochem       Date:  1972-06       Impact factor: 3.365

3.  The role of superoxide anion in the autoxidation of epinephrine and a simple assay for superoxide dismutase.

Authors:  H P Misra; I Fridovich
Journal:  J Biol Chem       Date:  1972-05-25       Impact factor: 5.157

4.  The role of catalytic superoxide formation in the O2 inhibition of nitroreductase.

Authors:  R P Mason; J L Holtzman
Journal:  Biochem Biophys Res Commun       Date:  1975-12-15       Impact factor: 3.575

5.  Protection from phenytoin-induced cognitive deficit by Bacopa monniera, a reputed Indian nootropic plant.

Authors:  D Vohora; S N Pal; K K Pillai
Journal:  J Ethnopharmacol       Date:  2000-08       Impact factor: 4.360

Review 6.  Nitrobenzene potential human cancer risk based on animal studies.

Authors:  J W Holder
Journal:  Toxicol Ind Health       Date:  1999-08       Impact factor: 2.273

Review 7.  Bacopa monniera, a reputed nootropic plant: an overview.

Authors:  A Russo; F Borrelli
Journal:  Phytomedicine       Date:  2005-04       Impact factor: 5.340

8.  Selenium: biochemical role as a component of glutathione peroxidase.

Authors:  J T Rotruck; A L Pope; H E Ganther; A B Swanson; D G Hafeman; W G Hoekstra
Journal:  Science       Date:  1973-02-09       Impact factor: 47.728

9.  Carcinogenicity and toxicity of inhaled nitrobenzene in B6C3F1 mice and F344 and CD rats.

Authors:  R C Cattley; J I Everitt; E A Gross; O R Moss; T E Hamm; J A Popp
Journal:  Fundam Appl Toxicol       Date:  1994-04

10.  Reduction of the carcinogen 1-nitropyrene to 1-aminopyrene by rat intestinal bacteria.

Authors:  P C Howard; F A Beland; C E Cerniglia
Journal:  Carcinogenesis       Date:  1983-08       Impact factor: 4.944
View more
  6 in total

Review 1.  A review of hepatoprotective plants used in saudi traditional medicine.

Authors:  Abdulrahman K Al-Asmari; Abdulrahman M Al-Elaiwi; Md Tanwir Athar; Mohammad Tariq; Ahmed Al Eid; Saeed M Al-Asmary
Journal:  Evid Based Complement Alternat Med       Date:  2014-12-18       Impact factor: 2.629

2.  Discovery of Lipid Peroxidation Inhibitors from Bacopa Species Prioritized through Multivariate Data Analysis and Multi-Informative Molecular Networking.

Authors:  Tongchai Saesong; Pierre-Marie Allard; Emerson Ferreira Queiroz; Laurence Marcourt; Nitra Nuengchamnong; Prapapan Temkitthawon; Nantaka Khorana; Jean-Luc Wolfender; Kornkanok Ingkaninan
Journal:  Molecules       Date:  2019-08-17       Impact factor: 4.411

3.  The effectiveness of Bacopa monnieri (Linn.) Wettst. as a nootropic, neuroprotective, or antidepressant supplement: analysis of the available clinical data.

Authors:  James M Brimson; Sirikalaya Brimson; Mani Iyer Prasanth; Premrutai Thitilertdecha; Dicson Sheeja Malar; Tewin Tencomnao
Journal:  Sci Rep       Date:  2021-01-12       Impact factor: 4.379

4.  Assessing the health hazard originated via pesticide chemicals in human through rabbit model in agricultural production system in Bangladesh.

Authors:  Amir Hossan Shaikat; Shahneaz Ali Khan; Mohammed Ashif Imtiaz; Md Ridoan Pasha; Jabin Sultana; Arfanul Saif; Mohammad Rashedul Alam
Journal:  BMC Pharmacol Toxicol       Date:  2022-04-28       Impact factor: 2.605

Review 5.  Pharmacological attributes of Bacopa monnieri extract: Current updates and clinical manifestation.

Authors:  Urooj Fatima; Sonam Roy; Shahnawaz Ahmad; Sabeeha Ali; Wafaa M Elkady; Ilyas Khan; Rana M Alsaffar; Mohd Adnan; Asimul Islam; Md Imtaiyaz Hassan
Journal:  Front Nutr       Date:  2022-08-18

6.  Acute and chronic toxicities of Bacopa monnieri extract in Sprague-Dawley rats.

Authors:  Seewaboon Sireeratawong; Kanjana Jaijoy; Parirat Khonsung; Nirush Lertprasertsuk; Kornkanok Ingkaninan
Journal:  BMC Complement Altern Med       Date:  2016-07-27       Impact factor: 3.659
  6 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.