Literature DB >> 21965337

Breast cancer stem cells, cytokine networks, and the tumor microenvironment.

Hasan Korkaya1, Suling Liu, Max S Wicha.   

Abstract

Many tumors, including breast cancer, are maintained by a subpopulation of cells that display stem cell properties, mediate metastasis, and contribute to treatment resistance. These cancer stem cells (CSCs) are regulated by complex interactions with the components of the tumor microenvironment - including mesenchymal stem cells, adipocytes, tumor associated fibroblasts, endothelial cells, and immune cells - through networks of cytokines and growth factors. Since these components have a direct influence on CSC properties, they represent attractive targets for therapeutic development.

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Year:  2011        PMID： 21965337      PMCID： PMC3223613          DOI： 10.1172/JCI57099

Source DB:  PubMed          Journal:  J Clin Invest        ISSN： 0021-9738            Impact factor:   14.808


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