Literature DB >> 21963736

Severe hyponatremia in association with I(131) therapy in a patient with metastatic thyroid cancer.

Tsukasa Nozu1, Yuri Yoshida, Masumi Ohira, Toshikatsu Okumura.   

Abstract

Hyponatremia is a common clinical problem that results from various causes. Hypothyroidism is known to be one of the causes of this disorder. We report a case of metastatic thyroid cancer presenting with severe hyponatremia in association with hypothyroidism induced by pretreatment of I(131) therapy, such as a low-iodine diet and withdrawal of thyroid hormone. Serum arginine vasopressin (AVP) was elevated and urine osmolality was higher than that of serum. Saline infusion and thyroid hormone replacement normalized serum sodium and AVP. Inappropriate secretion of AVP in hypothyroid state was thought to be one of the causes of this hyponatremia.

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Year:  2011        PMID： 21963736     DOI： 10.2169/internalmedicine.50.5740

Source DB:  PubMed          Journal:  Intern Med        ISSN： 0918-2918            Impact factor:   1.271


  8 in total

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  8 in total

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