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Literature DB >> 21963627

Identification of γ-AApeptides with potent and broad-spectrum antimicrobial activity.

Youhong Niu¹, Shruti Padhee¹, Haifan Wu¹, Ge Bai¹, Lacey Harrington², Whittney N Burda², Lindsey N Shaw², Chuanhai Cao³, Jianfeng Cai¹.

Abstract

We report the identification of a new class of antimicrobial peptidomimetics-γ-AApeptides with potent and broad-spectrum activity, including clinically-relevant strains that are unresponsive to most antibiotics. They are also not prone to select for drug-resistance.

Entities: Chemical Disease Species

Mesh：

Substances：

Year: 2011 PMID： 21963627 PMCID： PMC3746764 DOI： 10.1039/c1cc14476f

Source DB: PubMed Journal: Chem Commun (Camb) ISSN： 1359-7345 Impact factor: 6.222

16 in total

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Review 6. Multifunctional antimicrobial peptides: therapeutic targets in several human diseases.

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Review 8. De novo designed synthetic mimics of antimicrobial peptides.

Authors: Richard W Scott; William F DeGrado; Gregory N Tew
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9. Peptoids that mimic the structure, function, and mechanism of helical antimicrobial peptides.

Authors: Nathaniel P Chongsiriwatana; James A Patch; Ann M Czyzewski; Michelle T Dohm; Andrey Ivankin; David Gidalevitz; Ronald N Zuckermann; Annelise E Barron
Journal: Proc Natl Acad Sci U S A Date: 2008-02-19 Impact factor: 11.205

Review 10. Structure-function relationships in peptoids: recent advances toward deciphering the structural requirements for biological function.

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3. Polycarbonates with Potent and Selective Antimicrobial Activity toward Gram-Positive Bacteria.

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4. The development of antimicrobial a-AApeptides that suppress proinflammatory immune responses.

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5. Lipidated peptidomimetics with improved antimicrobial activity.

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Journal: ACS Med Chem Lett Date: 2012-07-12 Impact factor: 4.345

Review 6. The development of antimicrobial γ-AApeptides.

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8. Small Antimicrobial Agents Based on Acylated Reduced Amide Scaffold.

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Review 9. Antimicrobial AApeptides.

Authors: Peng Sang; Yan Shi; Peng Teng; Annie Cao; Hai Xu; Qi Li; Jianfeng Cai
Journal: Curr Top Med Chem Date: 2017 Impact factor: 3.295

10. Identification of novel inhibitors that disrupt STAT3-DNA interaction from a γ-AApeptide OBOC combinatorial library.

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