OBJECTIVE: We investigated the effect of various doses of vertical oscillation (vibration) on soleus H-reflex amplitude and post-activation depression in individuals with and without SCI. We also explored the acute effect of short-term limb vibration on skeletal muscle mRNA expression of genes associated with spinal plasticity. METHODS: Six healthy adults and five chronic complete SCI subjects received vibratory stimulation of their tibia over three different gravitational accelerations (0.3g, 0.6g, and 1.2g) at a fixed frequency (30Hz). Soleus H-reflexes were measured before, during, and after vibration. Two additional chronic complete SCI subjects had soleus muscle biopsies 3h following a single bout of vibration. RESULTS: H-reflex amplitude was depressed over 83% in both groups during vibration. This vibratory-induced inhibition lasted over 2min in the control group, but not in the SCI group. Post-activation depression was modulated during the long-lasting vibratory inhibition. A single bout of mechanical oscillation altered mRNA expression from selected genes associated with synaptic plasticity. CONCLUSIONS: Vibration of the lower leg inhibits the H-reflex amplitude, influences post-activation depression, and alters skeletal muscle mRNA expression of genes associated with synaptic plasticity. SIGNIFICANCE: Limb segment vibration may offer a long term method to reduce spinal reflex excitability after SCI.
OBJECTIVE: We investigated the effect of various doses of vertical oscillation (vibration) on soleus H-reflex amplitude and post-activation depression in individuals with and without SCI. We also explored the acute effect of short-term limb vibration on skeletal muscle mRNA expression of genes associated with spinal plasticity. METHODS: Six healthy adults and five chronic complete SCI subjects received vibratory stimulation of their tibia over three different gravitational accelerations (0.3g, 0.6g, and 1.2g) at a fixed frequency (30Hz). Soleus H-reflexes were measured before, during, and after vibration. Two additional chronic complete SCI subjects had soleus muscle biopsies 3h following a single bout of vibration. RESULTS: H-reflex amplitude was depressed over 83% in both groups during vibration. This vibratory-induced inhibition lasted over 2min in the control group, but not in the SCI group. Post-activation depression was modulated during the long-lasting vibratory inhibition. A single bout of mechanical oscillation altered mRNA expression from selected genes associated with synaptic plasticity. CONCLUSIONS: Vibration of the lower leg inhibits the H-reflex amplitude, influences post-activation depression, and alters skeletal muscle mRNA expression of genes associated with synaptic plasticity. SIGNIFICANCE: Limb segment vibration may offer a long term method to reduce spinal reflex excitability after SCI.
Authors: C Bosco; M Iacovelli; O Tsarpela; M Cardinale; M Bonifazi; J Tihanyi; M Viru; A De Lorenzo; A Viru Journal: Eur J Appl Physiol Date: 2000-04 Impact factor: 3.078
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