BACKGROUND: Pregnancy-associated plasma protein A (PAPP-A) proteolyzes insulin-like growth factor (IGF)-binding proteins and thus increases IGF-1 bioactivity. PAPP-A has been reported to be involved in various pathophysiologic abnormalities; however, the clinical significance of PAPP-A has not been examined in cases of heart failure (HF). We hypothesized that PAPP-A levels might be correlated with the severity of HF. METHODS AND RESULTS: PAPP-A and B-type natriuretic peptide (BNP) levels were measured in 262 subjects (182 HF patients and 80 control subjects). PAPP-A levels were higher in patients with HF than in control subjects and increased with advancing New York Heart Association functional class. There were 53 cardiac events during a mean follow-up period of 796 days. PAPP-A levels were higher in patients with cardiac events than in event-free patients. Patients were divided into 3 groups on the basis of their PAPP-A and BNP levels. Kaplan-Meier analysis demonstrated that the group with both high BNP with high PAPP-A had a significantly higher cardiac event rate than other groups. CONCLUSIONS: Serum PAPP-A levels were related to the severity of HF and associated with a high risk for adverse cardiac events in HF patients, suggesting that PAPP-A might be involved in the pathogenesis of HF.
BACKGROUND:Pregnancy-associated plasma protein A (PAPP-A) proteolyzes insulin-like growth factor (IGF)-binding proteins and thus increases IGF-1 bioactivity. PAPP-A has been reported to be involved in various pathophysiologic abnormalities; however, the clinical significance of PAPP-A has not been examined in cases of heart failure (HF). We hypothesized that PAPP-A levels might be correlated with the severity of HF. METHODS AND RESULTS:PAPP-A and B-type natriuretic peptide (BNP) levels were measured in 262 subjects (182 HF patients and 80 control subjects). PAPP-A levels were higher in patients with HF than in control subjects and increased with advancing New York Heart Association functional class. There were 53 cardiac events during a mean follow-up period of 796 days. PAPP-A levels were higher in patients with cardiac events than in event-free patients. Patients were divided into 3 groups on the basis of their PAPP-A and BNP levels. Kaplan-Meier analysis demonstrated that the group with both high BNP with high PAPP-A had a significantly higher cardiac event rate than other groups. CONCLUSIONS: Serum PAPP-A levels were related to the severity of HF and associated with a high risk for adverse cardiac events in HF patients, suggesting that PAPP-A might be involved in the pathogenesis of HF.
Authors: Lasse Bach Steffensen; Christian Bo Poulsen; Jeong Shim; Marie Bek; Kevin Jacobsen; Cheryl A Conover; Jacob Fog Bentzon; Claus Oxvig Journal: J Cardiovasc Transl Res Date: 2015-10-06 Impact factor: 4.132
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James T Becker; Nhat Trung Doan; Saskia P Hagenaars; Yasaman Saba; Gabriel Cuellar-Partida; Najaf Amin; Saima Hilal; Kwangsik Nho; Nazanin Mirza-Schreiber; Konstantinos Arfanakis; Diane M Becker; David Ames; Aaron L Goldman; Phil H Lee; Dorret I Boomsma; Simon Lovestone; Sudheer Giddaluru; Stephanie Le Hellard; Manuel Mattheisen; Marc M Bohlken; Dalia Kasperaviciute; Lianne Schmaal; Stephen M Lawrie; Ingrid Agartz; Esther Walton; Diana Tordesillas-Gutierrez; Gareth E Davies; Jean Shin; Jonathan C Ipser; Louis N Vinke; Martine Hoogman; Tianye Jia; Ralph Burkhardt; Marieke Klein; Fabrice Crivello; Deborah Janowitz; Owen Carmichael; Unn K Haukvik; Benjamin S Aribisala; Helena Schmidt; Lachlan T Strike; Ching-Yu Cheng; Shannon L Risacher; Benno Pütz; Debra A Fleischman; Amelia A Assareh; Venkata S Mattay; Randy L Buckner; Patrizia Mecocci; Anders M Dale; Sven Cichon; Marco P Boks; Mar Matarin; Brenda W J H Penninx; Vince D Calhoun; M Mallar Chakravarty; Andre F Marquand; Christine Macare; Shahrzad Kharabian Masouleh; Jaap Oosterlaan; Philippe Amouyel; Katrin Hegenscheid; Jerome I Rotter; Andrew J Schork; David C M Liewald; Greig I de Zubicaray; Tien Yin Wong; Li Shen; Philipp G Sämann; Henry Brodaty; Joshua L Roffman; Eco J C de Geus; Magda Tsolaki; Susanne Erk; Kristel R van Eijk; Gianpiero L Cavalleri; Nic J A van der Wee; Andrew M McIntosh; Randy L Gollub; Kazima B Bulayeva; Manon Bernard; Jennifer S Richards; Jayandra J Himali; Markus Loeffler; Nanda Rommelse; Wolfgang Hoffmann; Lars T Westlye; Maria C Valdés Hernández; Narelle K Hansell; Theo G M van Erp; Christiane Wolf; John B J Kwok; Bruno Vellas; Andreas Heinz; Loes M Olde Loohuis; Norman Delanty; Beng-Choon Ho; Christopher R K Ching; Elena Shumskaya; Baljeet Singh; Albert Hofman; Dennis van der Meer; Georg Homuth; Bruce M Psaty; Mark E Bastin; Grant W Montgomery; Tatiana M Foroud; Simone Reppermund; Jouke-Jan Hottenga; Andrew Simmons; Andreas Meyer-Lindenberg; Wiepke Cahn; Christopher D Whelan; Marjolein M J van Donkelaar; Qiong Yang; Norbert Hosten; Robert C Green; Anbupalam Thalamuthu; Sebastian Mohnke; Hilleke E Hulshoff Pol; Honghuang Lin; Clifford R Jack; Peter R Schofield; Thomas W Mühleisen; Pauline Maillard; Steven G Potkin; Wei Wen; Evan Fletcher; Arthur W Toga; Oliver Gruber; Matthew Huentelman; George Davey Smith; Lenore J Launer; Lars Nyberg; Erik G Jönsson; Benedicto Crespo-Facorro; Nastassja Koen; Douglas N Greve; André G Uitterlinden; Daniel R Weinberger; Vidar M Steen; Iryna O Fedko; Nynke A Groenewold; Wiro J Niessen; Roberto Toro; Christophe Tzourio; William T Longstreth; M Kamran Ikram; Jordan W Smoller; Marie-Jose van Tol; Jessika E Sussmann; Tomas Paus; Hervé Lemaître; Matthias L Schroeter; Bernard Mazoyer; Ole A Andreassen; Florian Holsboer; Chantal Depondt; Dick J Veltman; Jessica A Turner; Zdenka Pausova; Gunter Schumann; Daan van Rooij; Srdjan Djurovic; Ian J Deary; Katie L McMahon; Bertram Müller-Myhsok; Rachel M Brouwer; Hilkka Soininen; Massimo Pandolfo; Thomas H Wassink; Joshua W Cheung; Thomas Wolfers; Jean-Luc Martinot; Marcel P Zwiers; Matthias Nauck; Ingrid Melle; Nicholas G Martin; Ryota Kanai; Eric Westman; René S Kahn; Sanjay M Sisodiya; Tonya White; Arvin Saremi; Hans van Bokhoven; Han G Brunner; Henry Völzke; Margaret J Wright; Dennis van 't Ent; Markus M Nöthen; Roel A Ophoff; Jan K Buitelaar; Guillén Fernández; Perminder S Sachdev; Marcella Rietschel; Neeltje E M van Haren; Simon E Fisher; Alexa S Beiser; Clyde Francks; Andrew J Saykin; Karen A Mather; Nina Romanczuk-Seiferth; Catharina A Hartman; Anita L DeStefano; Dirk J Heslenfeld; Michael W Weiner; Henrik Walter; Pieter J Hoekstra; Paul A Nyquist; Barbara Franke; David A Bennett; Hans J Grabe; Andrew D Johnson; Christopher Chen; Cornelia M van Duijn; Oscar L Lopez; Myriam Fornage; Joanna M Wardlaw; Reinhold Schmidt; Charles DeCarli; Philip L De Jager; Arno Villringer; Stéphanie Debette; Vilmundur Gudnason; Sarah E Medland; Joshua M Shulman; Paul M Thompson; Sudha Seshadri; M Arfan Ikram Journal: Nat Genet Date: 2019-10-21 Impact factor: 38.330
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