| Literature DB >> 31636452 |
Claudia L Satizabal1,2,3,4, Hieab H H Adams5,6,7, Derrek P Hibar8, Charles C White9,10, Maria J Knol5, Jason L Stein8,11,12, Markus Scholz13,14, Muralidharan Sargurupremraj15, Neda Jahanshad8, Gennady V Roshchupkin5,6,16, Albert V Smith17,18,19, Joshua C Bis20, Xueqiu Jian21, Michelle Luciano22, Edith Hofer23,24, Alexander Teumer25, Sven J van der Lee5, Jingyun Yang26,27, Lisa R Yanek28, Tom V Lee29, Shuo Li30, Yanhui Hu31, Jia Yu Koh32, John D Eicher33, Sylvane Desrivières34, Alejandro Arias-Vasquez35,36,37,38, Ganesh Chauhan15,39, Lavinia Athanasiu40,41, Miguel E Rentería42, Sungeun Kim43,44,45, David Hoehn46, Nicola J Armstrong47, Qiang Chen48, Avram J Holmes49,50, Anouk den Braber51,52,53,54, Iwona Kloszewska55, Micael Andersson56,57, Thomas Espeseth40,58, Oliver Grimm59, Lucija Abramovic60, Saud Alhusaini61,62, Yuri Milaneschi63, Martina Papmeyer64,65, Tomas Axelsson66, Stefan Ehrlich50,67,68, Roberto Roiz-Santiañez69,70,71, Bernd Kraemer72, Asta K Håberg73,74, Hannah J Jones75,76,77, G Bruce Pike78,79, Dan J Stein80,81, Allison Stevens68, Janita Bralten36,38, Meike W Vernooij5,6, Tamara B Harris82, Irina Filippi83, A Veronica Witte84,85, Tulio Guadalupe86,87, Katharina Wittfeld88,89, Thomas H Mosley90, James T Becker91,92,93, Nhat Trung Doan41, Saskia P Hagenaars22, Yasaman Saba94, Gabriel Cuellar-Partida95, Najaf Amin5, Saima Hilal96,97, Kwangsik Nho43,44,45, Nazanin Mirza-Schreiber46,98, Konstantinos Arfanakis26,99,100, Diane M Becker28, David Ames101,102, Aaron L Goldman48, Phil H Lee50,103,104,105,106, Dorret I Boomsma51,52,53,107, Simon Lovestone108,109, Sudheer Giddaluru110,111, Stephanie Le Hellard110,111, Manuel Mattheisen112,113,114,115,116, Marc M Bohlken60, Dalia Kasperaviciute117,118, Lianne Schmaal119,120, Stephen M Lawrie64, Ingrid Agartz41,115,121, Esther Walton67,122, Diana Tordesillas-Gutierrez71,123, Gareth E Davies124, Jean Shin125, Jonathan C Ipser80, Louis N Vinke126, Martine Hoogman36,38, Tianye Jia34, Ralph Burkhardt14,127, Marieke Klein36,38, Fabrice Crivello128, Deborah Janowitz88, Owen Carmichael129, Unn K Haukvik40,130, Benjamin S Aribisala131,132, Helena Schmidt94, Lachlan T Strike95,133, Ching-Yu Cheng32,134, Shannon L Risacher44,45, Benno Pütz46, Debra A Fleischman26,27,135, Amelia A Assareh136, Venkata S Mattay48,137,138, Randy L Buckner50,139, Patrizia Mecocci140, Anders M Dale141,142,143,144,145, Sven Cichon146,147,148, Marco P Boks60, Mar Matarin117,149,150, Brenda W J H Penninx63, Vince D Calhoun151,152,153, M Mallar Chakravarty154,155, Andre F Marquand38,156, Christine Macare34, Shahrzad Kharabian Masouleh84,157, Jaap Oosterlaan158,159, Philippe Amouyel160,161,162,163, Katrin Hegenscheid164, Jerome I Rotter165, Andrew J Schork166,167, David C M Liewald22, Greig I de Zubicaray168,169, Tien Yin Wong32,170, Li Shen171, Philipp G Sämann46, Henry Brodaty136,172, Joshua L Roffman50, Eco J C de Geus51,52,53,107, Magda Tsolaki173, Susanne Erk174, Kristel R van Eijk175, Gianpiero L Cavalleri176, Nic J A van der Wee177,178, Andrew M McIntosh22,64, Randy L Gollub50,68,103, Kazima B Bulayeva179, Manon Bernard125, Jennifer S Richards35,38,180, Jayandra J Himali181,182,30, Markus Loeffler13,14, Nanda Rommelse37,38,183, Wolfgang Hoffmann89,184, Lars T Westlye40,41, Maria C Valdés Hernández131,185, Narelle K Hansell95,133, Theo G M van Erp186,187, Christiane Wolf188, John B J Kwok189,190,191, Bruno Vellas192,193, Andreas Heinz194, Loes M Olde Loohuis195, Norman Delanty61,196, Beng-Choon Ho197, Christopher R K Ching8,198, Elena Shumskaya36,38,156, Baljeet Singh199, Albert Hofman5,200, Dennis van der Meer40,41,201, Georg Homuth202, Bruce M Psaty20,203,204,205, Mark E Bastin131,185, Grant W Montgomery206, Tatiana M Foroud45,207, Simone Reppermund136,208, Jouke-Jan Hottenga51,52,53,107, Andrew Simmons209,210,211, Andreas Meyer-Lindenberg59, Wiepke Cahn60, Christopher D Whelan8,61, Marjolein M J van Donkelaar36,38, Qiong Yang30, Norbert Hosten164, Robert C Green103,212, Anbupalam Thalamuthu136, Sebastian Mohnke174, Hilleke E Hulshoff Pol60, Honghuang Lin181,213, Clifford R Jack214, Peter R Schofield190,215, Thomas W Mühleisen148,216,217, Pauline Maillard199, Steven G Potkin218, Wei Wen136, Evan Fletcher199, Arthur W Toga219, Oliver Gruber72, Matthew Huentelman167, George Davey Smith76, Lenore J Launer82, Lars Nyberg56,57,220, Erik G Jönsson41,115, Benedicto Crespo-Facorro70,71, Nastassja Koen80,81, Douglas N Greve68,221, André G Uitterlinden5,222, Daniel R Weinberger48,137,223,224,225, Vidar M Steen110,111, Iryna O Fedko51,52,107, Nynke A Groenewold80, Wiro J Niessen6,16,226, Roberto Toro227, Christophe Tzourio228, William T Longstreth204,229, M Kamran Ikram5,230, Jordan W Smoller50,103,105,106, Marie-Jose van Tol231, Jessika E Sussmann64, Tomas Paus232,233,234, Hervé Lemaître83, Matthias L Schroeter14,84,235, Bernard Mazoyer128, Ole A Andreassen40,41, Florian Holsboer46,236, Chantal Depondt237, Dick J Veltman63, Jessica A Turner152,153,238, Zdenka Pausova125, Gunter Schumann34, Daan van Rooij35,38,180, Srdjan Djurovic110,239, Ian J Deary22, Katie L McMahon168,169, Bertram Müller-Myhsok46,240,241, Rachel M Brouwer60, Hilkka Soininen242,243, Massimo Pandolfo237, Thomas H Wassink197, Joshua W Cheung8, Thomas Wolfers36,38, Jean-Luc Martinot83, Marcel P Zwiers38,156, Matthias Nauck244,245, Ingrid Melle40,41, Nicholas G Martin95, Ryota Kanai246,247,248, Eric Westman249, René S Kahn60,250, Sanjay M Sisodiya117,118, Tonya White6,251, Arvin Saremi8, Hans van Bokhoven36,38, Han G Brunner36,38,252,253, Henry Völzke25,245, Margaret J Wright133,254, Dennis van 't Ent51,52,53,107, Markus M Nöthen147,255, Roel A Ophoff195,256, Jan K Buitelaar35,38,183, Guillén Fernández35,38, Perminder S Sachdev136,257, Marcella Rietschel59, Neeltje E M van Haren60,251, Simon E Fisher38,87, Alexa S Beiser181,182,30, Clyde Francks38,87, Andrew J Saykin44,45,207, Karen A Mather136,190, Nina Romanczuk-Seiferth194, Catharina A Hartman180, Anita L DeStefano181,30, Dirk J Heslenfeld258, Michael W Weiner259,260, Henrik Walter174, Pieter J Hoekstra180, Paul A Nyquist28, Barbara Franke36,37,38, David A Bennett26,27, Hans J Grabe88,89, Andrew D Johnson33, Christopher Chen96,97, Cornelia M van Duijn5,261, Oscar L Lopez92,93, Myriam Fornage21,262, Joanna M Wardlaw22,185,263, Reinhold Schmidt23, Charles DeCarli264, Philip L De Jager9,10, Arno Villringer84,85, Stéphanie Debette182,15,228, Vilmundur Gudnason18,19, Sarah E Medland95, Joshua M Shulman29,265,266,267, Paul M Thompson8, Sudha Seshadri181,182, M Arfan Ikram268,269.
Abstract
Subcortical brain structures are integral to motion, consciousness, emotions and learning. We identified common genetic variation related to the volumes of the nucleus accumbens, amygdala, brainstem, caudate nucleus, globus pallidus, putamen and thalamus, using genome-wide association analyses in almost 40,000 individuals from CHARGE, ENIGMA and UK Biobank. We show that variability in subcortical volumes is heritable, and identify 48 significantly associated loci (40 novel at the time of analysis). Annotation of these loci by utilizing gene expression, methylation and neuropathological data identified 199 genes putatively implicated in neurodevelopment, synaptic signaling, axonal transport, apoptosis, inflammation/infection and susceptibility to neurological disorders. This set of genes is significantly enriched for Drosophila orthologs associated with neurodevelopmental phenotypes, suggesting evolutionarily conserved mechanisms. Our findings uncover novel biology and potential drug targets underlying brain development and disease.Entities:
Mesh：
Year: 2019 PMID： 31636452 PMCID： PMC7055269 DOI： 10.1038/s41588-019-0511-y
Source DB: PubMed Journal: Nat Genet ISSN： 1061-4036 Impact factor: 38.330