Atomistic simulations of electroporation in water preembedded membranes.

Atomistic simulations of electroporation were conducted on water/membrane/water systems, in which the membranes initially contained randomly distributed water molecules that might be introduced by acoustic treatment. The simulation results indicate that the critical strength of an applied electric field to induce electroporation is greatly reduced due to the initially embedded water molecules in the membranes. A lower applied electric field will significantly enhance the viability of cells in electroporation.