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Literature DB >> 23660813

Molecular dynamic simulation of transmembrane pore growth.

M Deminsky¹, A Eletskii, A Kniznik, A Odinokov, V Pentkovskii, B Potapkin.

Abstract

A molecular dynamic approach was applied for simulation of dynamics of pore formation and growth in a phospholipid bilayer in the presence of an external electric field. Processing the simulation results permitted recovery of the kinetic coefficients used in the Einstein-Smoluchowski equation describing the dynamics of pore evolution. Two different models of the bilayer membrane were considered: membrane consisting of POPC and POPE lipids. The simulations permitted us to find nonempirical values of the pore energy parameters, which are compared with empirical values. It was found that the parameters are sensitive to membrane type.

Entities: Chemical

Mesh：

Substances：

Year: 2013 PMID： 23660813 DOI： 10.1007/s00232-013-9552-9

Source DB: PubMed Journal: J Membr Biol ISSN： 0022-2631 Impact factor: 1.843

48 in total

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5. Reversible electrical breakdown of lipid bilayers: formation and evolution of pores.

Authors: R W Glaser; S L Leikin; L V Chernomordik; V F Pastushenko; A I Sokirko
Journal: Biochim Biophys Acta Date: 1988-05-24

6. Cell poration and cell fusion using an oscillating electric field.

Authors: D C Chang
Journal: Biophys J Date: 1989-10 Impact factor: 4.033

7. High-efficiency gene transfer into skeletal muscle mediated by electric pulses.

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8. Calcium-dependence of catecholamine release from bovine adrenal medullary cells after exposure to intense electric fields.

Authors: D E Knight; P F Baker
Journal: J Membr Biol Date: 1982 Impact factor: 1.843

Molecular dynamic simulation of transmembrane pore growth.

1. Nanoelectropulse-induced phosphatidylserine translocation.

2. Long-lasting plasma membrane permeabilization in mammalian cells by nanosecond pulsed electric field (nsPEF).

3. Ultrashort electric pulse induced changes in cellular dielectric properties.

4. Transport of siRNA through lipid membranes driven by nanosecond electric pulses: an experimental and computational study.

5. Reversible electrical breakdown of lipid bilayers: formation and evolution of pores.

6. Cell poration and cell fusion using an oscillating electric field.

7. High-efficiency gene transfer into skeletal muscle mediated by electric pulses.

8. Calcium-dependence of catecholamine release from bovine adrenal medullary cells after exposure to intense electric fields.

9. Kinetics, statistics, and energetics of lipid membrane electroporation studied by molecular dynamics simulations.

10. Electroporating fields target oxidatively damaged areas in the cell membrane.

1. An engineered membrane to measure electroporation: effect of tethers and bioelectronic interface.

2. Electric fields can control the transport of water in carbon nanotubes.

3. Cell electrofusion based on nanosecond/microsecond pulsed electric fields.