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Literature DB >> 21960006

Nucleolar protein Spindlin1 recognizes H3K4 methylation and stimulates the expression of rRNA genes.

Weixiang Wang¹, Zhi Chen, Zhuo Mao, Huihui Zhang, Xiaojun Ding, She Chen, Xiaodong Zhang, Ruiming Xu, Bing Zhu.

Abstract

The tandem Tudor-like domain-containing protein Spindlin1 has been reported to be a meiotic spindle-associated protein. Here we report that Spindlin1 is not associated with the spindle in mouse embryonic fibroblast cells during mitotic divisions. In interphase cells, Spindlin1 specifically localizes to the nucleoli. Moreover, Spindlin1 is a histone methylation effector protein that specifically recognizes H3K4 methylation. Finally, Spindlin1 localizes to the active ribosomal DNA (rDNA) repeats, and Spindlin1 facilitates the expression of rRNA genes.

Entities: Gene Species

Mesh：

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Year: 2011 PMID： 21960006 PMCID： PMC3207104 DOI： 10.1038/embor.2011.184

Source DB: PubMed Journal: EMBO Rep ISSN： 1469-221X Impact factor: 8.807

37 in total

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Authors: Jeesun Kim; Jeremy Daniel; Alexsandra Espejo; Aimee Lake; Murli Krishna; Li Xia; Yi Zhang; Mark T Bedford
Journal: EMBO Rep Date: 2006-01-13 Impact factor: 8.807

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Journal: Annu Rev Biochem Date: 2006 Impact factor: 23.643

4. Double chromodomains cooperate to recognize the methylated histone H3 tail.

Authors: John F Flanagan; Li-Zhi Mi; Maksymilian Chruszcz; Marcin Cymborowski; Katrina L Clines; Youngchang Kim; Wladek Minor; Fraydoon Rastinejad; Sepideh Khorasanizadeh
Journal: Nature Date: 2005-12-22 Impact factor: 49.962

5. Selective anchoring of TFIID to nucleosomes by trimethylation of histone H3 lysine 4.

Authors: Michiel Vermeulen; Klaas W Mulder; Sergei Denissov; W W M Pim Pijnappel; Frederik M A van Schaik; Radhika A Varier; Marijke P A Baltissen; Henk G Stunnenberg; Matthias Mann; H Th Marc Timmers
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Authors: Aurélie Comptour; Charlotte Moretti; Maria-Elisabetta Serrentino; Jana Auer; Côme Ialy-Radio; Monika A Ward; Aminata Touré; Daniel Vaiman; Julie Cocquet
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Review 4. Targeting epigenetic protein-protein interactions with small-molecule inhibitors.

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Review 5. Insights into newly discovered marks and readers of epigenetic information.

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6. A transcriptional coregulator, SPIN·DOC, attenuates the coactivator activity of Spindlin1.

Authors: Narkhyun Bae; Min Gao; Xu Li; Tolkappiyan Premkumar; Gianluca Sbardella; Junjie Chen; Mark T Bedford
Journal: J Biol Chem Date: 2017-10-23 Impact factor: 5.157

7. Novel sub-cellular localizations and intra-molecular interactions may define new functions of Mixed Lineage Leukemia protein.

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