BACKGROUND: Associations between acute respiratory inflammatory responses, changes in bronchial hyperresponsiveness, serum pneumoprotein levels, and exposure to fire smoke were studied. METHODS: The study comprised 51 firefighters. Blood samples were taken within 24 hr following exposure to fire smoke, and after a week and 3 months. Sputum was induced within 5 days post-exposure and subjects underwent spirometry and methacholine provocation one week post-exposure. Exposure was registered by a questionnaire. RESULTS: No changes were observed following smoke exposure in bronchial hyperresponsiveness and serum pneumoprotein levels. Nevertheless, in a sizable proportion of the firefighters (44%) elevated sputum neutrophil levels (≥60%) were found. Serum IL-8 concentrations were higher 24 hr post-exposure compared to pre-exposure. Elevated neutrophil levels in sputum were associated with elevated serum IL-8 (β = 0.010, P = 0.004) and TNFα (β = 0.005, P = 0.034) levels within 24 hr post-exposure and IL-8 elevation lasted up to 3 months. CONCLUSIONS: Acute exposure to fire smoke induces acute neutrophilic airway and long-lasting systemic inflammation in healthy firefighters in the absence of bronchial hyperresponsiveness.
BACKGROUND: Associations between acute respiratory inflammatory responses, changes in bronchial hyperresponsiveness, serum pneumoprotein levels, and exposure to fire smoke were studied. METHODS: The study comprised 51 firefighters. Blood samples were taken within 24 hr following exposure to fire smoke, and after a week and 3 months. Sputum was induced within 5 days post-exposure and subjects underwent spirometry and methacholine provocation one week post-exposure. Exposure was registered by a questionnaire. RESULTS: No changes were observed following smoke exposure in bronchial hyperresponsiveness and serum pneumoprotein levels. Nevertheless, in a sizable proportion of the firefighters (44%) elevated sputum neutrophil levels (≥60%) were found. Serum IL-8 concentrations were higher 24 hr post-exposure compared to pre-exposure. Elevated neutrophil levels in sputum were associated with elevated serum IL-8 (β = 0.010, P = 0.004) and TNFα (β = 0.005, P = 0.034) levels within 24 hr post-exposure and IL-8 elevation lasted up to 3 months. CONCLUSIONS: Acute exposure to fire smoke induces acute neutrophilic airway and long-lasting systemic inflammation in healthy firefighters in the absence of bronchial hyperresponsiveness.
Authors: Anna M Adetona; Olorunfemi Adetona; Robert M Gogal; David Diaz-Sanchez; Stephen L Rathbun; Luke P Naeher Journal: J Occup Environ Med Date: 2017-07 Impact factor: 2.162
Authors: Denise M Gaughan; David C Christiani; Michael D Hughes; Dorothee M Baur; Lester Kobzik; Gregory R Wagner; Stefanos N Kales Journal: Am J Ind Med Date: 2013-09-20 Impact factor: 2.214
Authors: Tjard R Schermer; Winifred Malbon; Michael Morgan; Michael Smith; Alan J Crockett Journal: Int Arch Occup Environ Health Date: 2014-02-26 Impact factor: 3.015
Authors: Katrin Dierschke; Christina Isaxon; Ulla B K Andersson; Eva Assarsson; Anna Axmon; Leo Stockfelt; Anders Gudmundsson; Bo A G Jönsson; Monica Kåredal; Jakob Löndahl; Joakim Pagels; Aneta Wierzbicka; Mats Bohgard; Jörn Nielsen Journal: Int Arch Occup Environ Health Date: 2017-03-03 Impact factor: 3.015