Literature DB >> 21959281

Ezogabine (retigabine).

Carl E Stafstrom1, Seden Grippon, Peter Kirkpatrick.   

Abstract

Ezogabine (Potiga; Valeant Pharmaceuticals/GlaxoSmithKline), a potassium channel opener, was approved in June 2011 by the U.S. Food and Drug Administration (F.D.A.) for the adjunctive treatment of partial-onset seizures in adult patients. The same drug was granted marketing authorization for this indication in the European Union in March 2011, where it is known as retigabine (Trobalt).

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Year:  2011        PMID: 21959281     DOI: 10.1038/nrd3561

Source DB:  PubMed          Journal:  Nat Rev Drug Discov        ISSN: 1474-1776            Impact factor:   84.694


  8 in total

Review 1.  Key factors in the discovery and development of new antiepileptic drugs.

Authors:  Meir Bialer; H Steve White
Journal:  Nat Rev Drug Discov       Date:  2010-01       Impact factor: 84.694

2.  Ezogabine: a new angle on potassium gates.

Authors:  Edward Faught
Journal:  Epilepsy Curr       Date:  2011-05       Impact factor: 7.500

3.  Efficacy of new antiepileptic drugs.

Authors:  Dieter Schmidt
Journal:  Epilepsy Curr       Date:  2011-01       Impact factor: 7.500

4.  Randomized, double-blind, placebo-controlled trial of ezogabine (retigabine) in partial epilepsy.

Authors:  J A French; B W Abou-Khalil; R F Leroy; E M T Yacubian; P Shin; S Hall; H Mansbach; V Nohria
Journal:  Neurology       Date:  2011-03-30       Impact factor: 9.910

5.  The new anticonvulsant retigabine (D-23129) acts as an opener of K+ channels in neuronal cells.

Authors:  C Rundfeldt
Journal:  Eur J Pharmacol       Date:  1997-10-08       Impact factor: 4.432

6.  Efficacy and safety of adjunctive ezogabine (retigabine) in refractory partial epilepsy.

Authors:  M J Brodie; H Lerche; A Gil-Nagel; C Elger; S Hall; P Shin; V Nohria; H Mansbach
Journal:  Neurology       Date:  2010-10-13       Impact factor: 9.910

7.  Randomized, multicenter, dose-ranging trial of retigabine for partial-onset seizures.

Authors:  R J Porter; A Partiot; R Sachdeo; V Nohria; W M Alves
Journal:  Neurology       Date:  2007-04-10       Impact factor: 9.910

8.  D-23129: a new anticonvulsant with a broad spectrum activity in animal models of epileptic seizures.

Authors:  A Rostock; C Tober; C Rundfeldt; R Bartsch; J Engel; E E Polymeropoulos; B Kutscher; W Löscher; D Hönack; H S White; H H Wolf
Journal:  Epilepsy Res       Date:  1996-04       Impact factor: 3.045

  8 in total
  25 in total

Review 1.  Subcellular localization of K+ channels in mammalian brain neurons: remarkable precision in the midst of extraordinary complexity.

Authors:  James S Trimmer
Journal:  Neuron       Date:  2015-01-21       Impact factor: 17.173

2.  Concomitant facilitation of GABAA receptors and KV7 channels by the non-opioid analgesic flupirtine.

Authors:  Felicia Klinger; Petra Geier; Mario M Dorostkar; Giri K Chandaka; Arsalan Yousuf; Isabella Salzer; Helmut Kubista; Stefan Boehm
Journal:  Br J Pharmacol       Date:  2012-07       Impact factor: 8.739

3.  Prevention of brain damage after traumatic brain injury by pharmacological enhancement of KCNQ (Kv7, "M-type") K+ currents in neurons.

Authors:  Fabio A Vigil; Eda Bozdemir; Vladislav Bugay; Sang H Chun; MaryAnn Hobbs; Isamar Sanchez; Shayne D Hastings; Rafael J Veraza; Deborah M Holstein; Shane M Sprague; Chase M Carver; Jose E Cavazos; Robert Brenner; James D Lechleiter; Mark S Shapiro
Journal:  J Cereb Blood Flow Metab       Date:  2019-07-04       Impact factor: 6.200

Review 4.  HCN Channel Targets for Novel Antidepressant Treatment.

Authors:  Stacy M Ku; Ming-Hu Han
Journal:  Neurotherapeutics       Date:  2017-07       Impact factor: 7.620

5.  Activity-dependent transcriptional regulation of M-Type (Kv7) K(+) channels by AKAP79/150-mediated NFAT actions.

Authors:  Jie Zhang; Mark S Shapiro
Journal:  Neuron       Date:  2012-12-20       Impact factor: 17.173

6.  Cardiovascular responses to retigabine in conscious rats--under normotensive and hypertensive conditions.

Authors:  L V Fretwell; J Woolard
Journal:  Br J Pharmacol       Date:  2013-07       Impact factor: 8.739

7.  Discovery of Aromatic Carbamates that Confer Neuroprotective Activity by Enhancing Autophagy and Inducing the Anti-Apoptotic Protein B-Cell Lymphoma 2 (Bcl-2).

Authors:  Nihar Kinarivala; Ronak Patel; Rose-Mary Boustany; Abraham Al-Ahmad; Paul C Trippier
Journal:  J Med Chem       Date:  2017-11-22       Impact factor: 7.446

8.  Modulation of the heart's electrical properties by the anticonvulsant drug retigabine.

Authors:  Lena Rubi; Michael Kovar; Eva Zebedin-Brandl; Xaver Koenig; Manuel Dominguez-Rodriguez; Hannes Todt; Helmut Kubista; Stefan Boehm; Karlheinz Hilber
Journal:  Toxicol Appl Pharmacol       Date:  2017-06-20       Impact factor: 4.219

9.  Myelin loss and axonal ion channel adaptations associated with gray matter neuronal hyperexcitability.

Authors:  Mustafa S Hamada; Maarten H P Kole
Journal:  J Neurosci       Date:  2015-05-06       Impact factor: 6.167

10.  Molecular basis for ligand activation of the human KCNQ2 channel.

Authors:  Xiaoxiao Li; Qiansen Zhang; Peipei Guo; Jie Fu; Lianghe Mei; Dashuai Lv; Jiangqin Wang; Dongwu Lai; Sheng Ye; Huaiyu Yang; Jiangtao Guo
Journal:  Cell Res       Date:  2020-09-03       Impact factor: 25.617

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