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Literature DB >> 21686305

Ezogabine: a new angle on potassium gates.

Abstract

Ezogabine is a new drug for adjunctive therapy of partial-onset seizures with a novel mechanism of action. As a potassium-channel facilitator, it promotes membrane repolarization and thus opposes rapid repetitive discharges. Side effects are typical for antiepileptic drugs and the safety profile is good. Occasional instances of urinary difficulty may require surveillance.

Entities: Chemical Disease

Year: 2011 PMID： 21686305 PMCID： PMC3117495 DOI： 10.5698/1535-7511-11.3.75

Source DB: PubMed Journal: Epilepsy Curr ISSN： 1535-7511 Impact factor: 7.500

24 in total

1. AWD 140-190: a new anticonvulsant with a very good margin of safety.

Authors: A Rostock; C Tober; C Rundfeldt; R Bartsch; K Unverferth; J Engel; H H Wolf; H S White
Journal: Epilepsy Res Date: 1997-07 Impact factor: 3.045

Review 2. Placebo-corrected efficacy of modern antiepileptic drugs for refractory epilepsy: systematic review and meta-analysis.

Authors: Stefan Beyenburg; Knut Stavem; Dieter Schmidt
Journal: Epilepsia Date: 2009-09-10 Impact factor: 5.864

3. The new anticonvulsant retigabine favors voltage-dependent opening of the Kv7.2 (KCNQ2) channel by binding to its activation gate.

Authors: Thomas V Wuttke; Guiscard Seebohm; Sigrid Bail; Snezana Maljevic; Holger Lerche
Journal: Mol Pharmacol Date: 2005-01-20 Impact factor: 4.436

4. The effects of D-23129, a new experimental anticonvulsant drug, on neurotransmitter amino acids in the rat hippocampus in vitro.

Authors: I M Kapetanovic; W D Yonekawa; H J Kupferberg
Journal: Epilepsy Res Date: 1995-11 Impact factor: 3.045

Ezogabine: a new angle on potassium gates.

1. AWD 140-190: a new anticonvulsant with a very good margin of safety.

Review 2. Placebo-corrected efficacy of modern antiepileptic drugs for refractory epilepsy: systematic review and meta-analysis.

3. The new anticonvulsant retigabine favors voltage-dependent opening of the Kv7.2 (KCNQ2) channel by binding to its activation gate.

4. The effects of D-23129, a new experimental anticonvulsant drug, on neurotransmitter amino acids in the rat hippocampus in vitro.

5. Efficacy and safety of adjunctive ezogabine (retigabine) in refractory partial epilepsy.

6. Multiple-dose, linear, dose-proportional pharmacokinetics of retigabine in healthy volunteers.

Review 7. Ion channel defects in idiopathic epilepsies.

8. D-23129: a potent anticonvulsant in the amygdala kindling model of complex partial seizures.

9. Lack of pharmacokinetic interaction between retigabine and phenobarbitone at steady-state in healthy subjects.

10. Randomized, multicenter, dose-ranging trial of retigabine for partial-onset seizures.

1. Ezogabine (retigabine).

Review 2. New antiepileptic medication linked to blue discoloration of the skin and eyes.

3. Clinical utility of adjunctive retigabine in partial onset seizures in adults.