Literature DB >> 21959271

Where will new neuroscience therapies come from?

Darryle D Schoepp1.   

Abstract

The challenges of developing drugs for central nervous system disorders have led some major companies to reduce or discontinue investment in the field, even though the unmet medical need is substantial. How can the wealth of basic research knowledge in neuroscience be successfully translated into new therapies?

Entities:  

Mesh：

Substances：

Year:  2011        PMID： 21959271     DOI： 10.1038/nrd3559

Source DB:  PubMed          Journal:  Nat Rev Drug Discov        ISSN： 1474-1776            Impact factor:   84.694


  8 in total

1.  Modulatory effects of activation of metabotropic glutamate receptors on GABAergic circuits in the mouse thalamus.

Authors:  Tingting Liu; Iraklis Petrof; S Murray Sherman
Journal:  J Neurophysiol       Date:  2015-02-04       Impact factor: 2.714

2.  Quantitative systems pharmacology as an extension of PK/PD modeling in CNS research and development.

Authors:  Hugo Geerts; Athan Spiros; Patrick Roberts; Robert Carr
Journal:  J Pharmacokinet Pharmacodyn       Date:  2013-01-22       Impact factor: 2.745

3.  Mining mouse behavior for patterns predicting psychiatric drug classification.

Authors:  Neri Kafkafi; Cheryl L Mayo; Greg I Elmer
Journal:  Psychopharmacology (Berl)       Date:  2014-01       Impact factor: 4.530

4.  All-Optical Electrophysiology for Disease Modeling and Pharmacological Characterization of Neurons.

Authors:  Christopher A Werley; Ted Brookings; Hansini Upadhyay; Luis A Williams; Owen B McManus; Graham T Dempsey
Journal:  Curr Protoc Pharmacol       Date:  2017-09-11

5.  Allosteric ligands for the pharmacologically dark receptors GPR68 and GPR65.

Authors:  Xi-Ping Huang; Joel Karpiak; Wesley K Kroeze; Hu Zhu; Xin Chen; Sheryl S Moy; Kara A Saddoris; Viktoriya D Nikolova; Martilias S Farrell; Sheng Wang; Thomas J Mangano; Deepak A Deshpande; Alice Jiang; Raymond B Penn; Jian Jin; Beverly H Koller; Terry Kenakin; Brian K Shoichet; Bryan L Roth
Journal:  Nature       Date:  2015-11-09       Impact factor: 49.962

6.  A safe lithium mimetic for bipolar disorder.

Authors:  Nisha Singh; Amy C Halliday; Justyn M Thomas; Olga V Kuznetsova; Rhiannon Baldwin; Esther C Y Woon; Parvinder K Aley; Ivi Antoniadou; Trevor Sharp; Sridhar R Vasudevan; Grant C Churchill
Journal:  Nat Commun       Date:  2013       Impact factor: 14.919

7.  Highly Parallelized, Multicolor Optogenetic Recordings of Cellular Activity for Therapeutic Discovery Applications in Ion Channels and Disease-Associated Excitable Cells.

Authors:  Gabriel B Borja; Hongkang Zhang; Benjamin N Harwood; Jane Jacques; Jennifer Grooms; Romina O Chantre; Dawei Zhang; Adam Barnett; Christopher A Werley; Yang Lu; Steven F Nagle; Owen B McManus; Graham T Dempsey
Journal:  Front Mol Neurosci       Date:  2022-07-04       Impact factor: 6.261

8.  Effects of ethanolic extract of Fumaria indica L. on rat cognitive dysfunctions.

Authors:  Gireesh Kumar Singh; Geeta Rai; Shyam Sunder Chatterjee; Vikas Kumar
Journal:  Ayu       Date:  2013-10
  8 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.