Literature DB >> 2194836

Metal ion co-ordination in the DNA binding domain of the yeast transcriptional activator GAL4.

J F Povey1, G P Diakun, C D Garner, S P Wilson, E D Laue.   

Abstract

The structure of the DNA binding domain of the yeast transcriptional activator GAL4 was investigated by extended X-ray fine structure (e.x.a.f.s.). Two samples of GAL4 were studied, one containing cadmium as a structural probe (Cd(II)GAL4) and the other containing the 'native' zinc (Zn(II)-GAL4). The results suggest that the structure of the DNA binding domain of GAL4 contains a two metal ion cluster distinguishing it from the 'zinc finger' proteins typified by the Xenopus laevis transcription factor TFIIIA.

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Year:  1990        PMID： 2194836     DOI： 10.1016/0014-5793(90)81525-s

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  5 in total

1.  Ab initio self-consistent x-ray absorption fine structure analysis for metalloproteins.

Authors:  Nicholas Dimakis; Grant Bunker
Journal:  Biophys J       Date:  2006-09-29       Impact factor: 4.033

2.  A physico-chemical investigation of the self-association of the DNA binding domain of the yeast transcriptional activator GAL4.

Authors:  P Gadhavi; P J Morgan; P Alefounder; S E Harding
Journal:  Eur Biophys J       Date:  1996       Impact factor: 1.733

3.  Refined solution structure of the DNA-binding domain of GAL4 and use of 3J(113Cd,1H) in structure determination.

Authors:  J D Baleja; V Thanabal; G Wagner
Journal:  J Biomol NMR       Date:  1997-12       Impact factor: 2.835

4.  Relationship between zinc content and DNA-binding activity of the DNA-binding motif of the transcription factor ALCR in Aspergillus nidulans.

Authors:  D Sequeval; B Felenbok
Journal:  Mol Gen Genet       Date:  1994-01

5.  Effects of DNA binding and metal substitution on the dynamics of the GAL4 DNA-binding domain as studied by amide proton exchange.

Authors:  T Mau; J D Baleja; G Wagner
Journal:  Protein Sci       Date:  1992-11       Impact factor: 6.725
  5 in total

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