| Literature DB >> 21943844 |
S Thee1, E W Zöllner, M Willemse, A C Hesseling, K Magdorf, H S Schaaf.
Abstract
Ethionamide (ETH) treatment may cause hypothyroidism. Clinical data, serum thyroid stimulating hormone (TSH) and free thyroxine (fT4) levels were retrospectively assessed in 137 children receiving anti-tuberculosis treatment including ETH. Abnormal thyroid function tests (TFTs) were recorded in 79 (58%) children: elevated serum TSH and suppressed fT4 (n = 30), isolated elevated serum TSH (n = 20), isolated low serum fT4 (n = 28) and isolated low TSH (n = 1). The risk for biochemical hypothyroidism was higher for children on regimens including para-aminosalicylic acid and in human immunodeficiency virus infected children. TFT abnormalities are frequent in children on ETH and are mainly due to primary hypothyroidism or euthyroid sick syndrome.Entities:
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Year: 2011 PMID： 21943844 DOI： 10.5588/ijtld.10.0707
Source DB: PubMed Journal: Int J Tuberc Lung Dis ISSN： 1027-3719 Impact factor: 2.373