| Literature DB >> 22907397 |
Aspasia Katragkou1, Charalampos Antachopoulos, Elpis Hatziagorou, Maria Sdougka, Emmanuel Roilides, John Tsanakas.
Abstract
Extensively drug-resistant (XDR) tuberculosis (TB) represents a serious and growing problem in both endemic and non-endemic countries. We describe a 2.5-year-old girl with XDR-pulmonary TB and an 18-month-old boy with pre-XDR-central nervous system TB. Patients received individualized treatment with second-line anti-TB agents based on genotypic and phenotypic drug susceptibility testing results. Both children achieved culture conversion 3 months and 1 month after treatment initiation, respectively. The child with XDR-pulmonary TB showed evidence of cure while treatment adverse events were managed without treatment interruption. The child with pre-XDR-central nervous system TB after 6-month hospitalization with multiple infectious complications had a dismal end due to hepatic insufficiency possibly related to anti-TB treatment. This is the first report of children with pre-XDR and XDR TB in Greece, emphasizing the public health dimensions and management complexity of XDR TB.Entities:
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Year: 2012 PMID： 22907397 DOI： 10.1007/s00431-012-1811-8
Source DB: PubMed Journal: Eur J Pediatr ISSN： 0340-6199 Impact factor: 3.183