INTRODUCTION: Thigh swelling in an infant can be a symptom of a simple benign condition or a life-threatening condition. We observed a cluster of thigh swelling episodes in infants in which the cause was Bacillus Calmette-Guérin-related cold thigh abscess. We report this unusual case series to raise awareness about this diagnosis. CASE PRESENTATIONS: We performed a retrospective review of five infants (four boys and one girl) who presented with Bacillus Calmette-Guérin-related left thigh abscess. The swelling was noticed by the parents at a mean period of three months prior to presentation. The ages at presentation were five, five, eight and nine months for the boys, and six months for the girl. All of the patients were healthy Saudi infants, and received the Bacillus Calmette-Guérin vaccine at birth. Clinically, all of the patients were well and did not demonstrate signs of systemic infection. All patients underwent needle aspiration, with subsequent incision and drainage in four of the five cases. The cultures obtained from the abscess fluids were the key to establishing the diagnosis. Only three patients (60%) received antituberculosis drugs. Wound healing lasted for a mean period of approximately seven months. Two-year follow-up was unremarkable for all of our patients. CONCLUSIONS: Technical errors continue to be significant in the development of vaccine-related complications. Bacillus Calmette-Guérin-related cold thigh abscess is an extremely rare entity.
INTRODUCTION: Thigh swelling in an infant can be a symptom of a simple benign condition or a life-threatening condition. We observed a cluster of thigh swelling episodes in infants in which the cause was Bacillus Calmette-Guérin-related cold thigh abscess. We report this unusual case series to raise awareness about this diagnosis. CASE PRESENTATIONS: We performed a retrospective review of five infants (four boys and one girl) who presented with Bacillus Calmette-Guérin-related left thigh abscess. The swelling was noticed by the parents at a mean period of three months prior to presentation. The ages at presentation were five, five, eight and nine months for the boys, and six months for the girl. All of the patients were healthy Saudi infants, and received the Bacillus Calmette-Guérin vaccine at birth. Clinically, all of the patients were well and did not demonstrate signs of systemic infection. All patients underwent needle aspiration, with subsequent incision and drainage in four of the five cases. The cultures obtained from the abscess fluids were the key to establishing the diagnosis. Only three patients (60%) received antituberculosis drugs. Wound healing lasted for a mean period of approximately seven months. Two-year follow-up was unremarkable for all of our patients. CONCLUSIONS: Technical errors continue to be significant in the development of vaccine-related complications. Bacillus Calmette-Guérin-related cold thigh abscess is an extremely rare entity.
Authors: Shelley L Deeks; Michael Clark; David W Scheifele; Barbara J Law; Meenakshi Dawar; Nooshin Ahmadipour; Wikke Walop; C Edward Ellis; Arlene King Journal: Pediatr Infect Dis J Date: 2005-06 Impact factor: 2.129
Authors: Somsak Thamthitiwat; Nongnush Marin; Henry C Baggett; Leonard F Peruski; Wannachai Kiatkulwiwat; Veerachai Panumatrasmee; Jay K Varma; Sriprapa Nateniyom; Pasakorn Akarasewi; Susan A Maloney Journal: Vaccine Date: 2011-01-05 Impact factor: 3.641
Authors: Wael A H Hegazy; R Al Mamari; K Almazroui; A Al Habsi; A Kamona; H AlHarthi; Areej I Al Lawati; AlZahra H AlHusaini Journal: J Epidemiol Glob Health Date: 2021-04-26