| Literature DB >> 21215347 |
Somsak Thamthitiwat1, Nongnush Marin, Henry C Baggett, Leonard F Peruski, Wannachai Kiatkulwiwat, Veerachai Panumatrasmee, Jay K Varma, Sriprapa Nateniyom, Pasakorn Akarasewi, Susan A Maloney.
Abstract
We describe four cases of Mycobacterium tuberculosis complex bacteremia diagnosed in immunocompetent neonates, who presented with high fever and/or jaundice within 72 h after Bacille Calmette-Guérin (BCG) vaccination. All neonates were hospitalized, and none received anti-mycobacterial therapy. All recovered completely and remain healthy 2-3.5 years later. Genotyping of one available isolate identified the pathogen as Mycobacterium bovis BCG. The similar clinical presentations and close temporal association between BCG vaccination and illness suggest that all four neonates likely had BCG bacteremia. BCG bacteremia shortly following vaccination among healthy neonates has not been previously described and merits further study to determine its frequency and clinical significance.Entities:
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Year: 2011 PMID： 21215347 DOI： 10.1016/j.vaccine.2010.12.089
Source DB: PubMed Journal: Vaccine ISSN： 0264-410X Impact factor: 3.641