Literature DB >> 21935709

Elk-1 interacts with dynein upon serum stimulation but independent of serine 383 phosphorylation.

Ozlem Demir1, Oya Ari, Isil Aksan Kurnaz.   

Abstract

Elk-1 belongs to the Ternary Complex Factor (TCF) subfamily of the ETS (from E26 viral oncogene) domain superfamily of transcription factors, and has been known as a regulator of mitogen-induced immediate early gene transcription upon Mitogen Activated Protein Kinase (MAPK) activation. Elk-1 has been previously shown to interact with neuronal microtubules, and here we show that P-S383-Elk-1, in addition to co-localizing with motor proteins kinesin, Eg5 and Mitotik Kinesin-Like Protein (MKLP) at the mitotic spindles, it physically interacts with dynein in a serum induction-dependent but Ser383 phosphorylation-independent manner.

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Year:  2011        PMID： 21935709     DOI： 10.1007/s10571-011-9750-x

Source DB:  PubMed          Journal:  Cell Mol Neurobiol        ISSN： 0272-4340            Impact factor:   5.046


  10 in total

1.  The mechanism of phosphorylation-inducible activation of the ETS-domain transcription factor Elk-1.

Authors:  S H Yang; P Shore; N Willingham; J H Lakey; A D Sharrocks
Journal:  EMBO J       Date:  1999-10-15       Impact factor: 11.598

2.  Elk-1 interacts with neuronal microtubules and relocalizes to the nucleus upon phosphorylation.

Authors:  Ozlem Demir; Sirin Korulu; Aysegul Yildiz; Arzu Karabay; Isil Aksan Kurnaz
Journal:  Mol Cell Neurosci       Date:  2008-10-28       Impact factor: 4.314

3.  In vivo expression and regulation of Elk-1, a target of the extracellular-regulated kinase signaling pathway, in the adult rat brain.

Authors:  V Sgambato; P Vanhoutte; C Pagès; M Rogard; R Hipskind; M J Besson; J Caboche
Journal:  J Neurosci       Date:  1998-01-01       Impact factor: 6.167

4.  ETS-domain transcription factor Elk-1 mediates neuronal survival: SMN as a potential target.

Authors:  Ozlem Demir; Nese Aysit; Zeynep Onder; Nezaket Turkel; Gurkan Ozturk; Andrew D Sharrocks; Isil Aksan Kurnaz
Journal:  Biochim Biophys Acta       Date:  2011-03-17

5.  The Elk-1 ETS-domain transcription factor contains a mitogen-activated protein kinase targeting motif.

Authors:  S H Yang; P R Yates; A J Whitmarsh; R J Davis; A D Sharrocks
Journal:  Mol Cell Biol       Date:  1998-02       Impact factor: 4.272

6.  Kif15 cooperates with eg5 to promote bipolar spindle assembly.

Authors:  Marvin E Tanenbaum; Libor Macůrek; Aniek Janssen; Erica F Geers; Mónica Alvarez-Fernández; René H Medema
Journal:  Curr Biol       Date:  2009-10-08       Impact factor: 10.834

7.  Wildtype Elk-1, but not a SUMOylation mutant, represses egr-1 expression in SH-SY5Y neuroblastomas.

Authors:  O Demir; I Aksan Kurnaz
Journal:  Neurosci Lett       Date:  2008-03-27       Impact factor: 3.046

Review 8.  Ets ternary complex transcription factors.

Authors:  Gilles Buchwalter; Christian Gross; Bohdan Wasylyk
Journal:  Gene       Date:  2004-01-07       Impact factor: 3.688

Review 9.  Mitotic functions of kinesin-5.

Authors:  Nick P Ferenz; Alyssa Gable; Pat Wadsworth
Journal:  Semin Cell Dev Biol       Date:  2010-01-28       Impact factor: 7.727

10.  Ternary complex factor-serum response factor complex-regulated gene activity is required for cellular proliferation and inhibition of apoptotic cell death.

Authors:  Elaine R Vickers; Aneta Kasza; Isil Aksan Kurnaz; Anne Seifert; Leo A H Zeef; Amanda O'donnell; Andy Hayes; Andrew D Sharrocks
Journal:  Mol Cell Biol       Date:  2004-12       Impact factor: 4.272
  10 in total

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