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Literature DB >> 20109572

Mitotic functions of kinesin-5.

Nick P Ferenz¹, Alyssa Gable, Pat Wadsworth.

Abstract

In all eukaryotic cells, molecular motor proteins play essential roles in spindle assembly and function. The homotetrameric kinesin-5 motors in particular generate outward forces that establish and maintain spindle bipolarity and contribute to microtubule flux. Cell-cycle dependent phosphorylation of kinesin-5 motors regulates their localization to the mitotic spindle. Analysis of live cells further shows that kinesin-5 motors are highly dynamic in the spindle. Understanding the interactions of kinesin-5 motors with microtubules and other spindle proteins is likely to broaden the documented roles of kinesin-5 motors during cell division. Copyright 2010 Elsevier Ltd. All rights reserved.

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Year: 2010 PMID： 20109572 PMCID： PMC2844466 DOI： 10.1016/j.semcdb.2010.01.019

Source DB: PubMed Journal: Semin Cell Dev Biol ISSN： 1084-9521 Impact factor: 7.727

71 in total

1. Cell cycle-dependent changes in microtubule dynamics in living cells expressing green fluorescent protein-alpha tubulin.

Authors: N M Rusan; C J Fagerstrom; A M Yvon; P Wadsworth
Journal: Mol Biol Cell Date: 2001-04 Impact factor: 4.138

2. Poleward microtubule flux is a major component of spindle dynamics and anaphase a in mitotic Drosophila embryos.

Authors: Paul Maddox; Arshad Desai; Karen Oegema; Timothy J Mitchison; E D Salmon
Journal: Curr Biol Date: 2002-10-01 Impact factor: 10.834

3. Mitotic spindle organization by a plus-end-directed microtubule motor.

Authors: K E Sawin; K LeGuellec; M Philippe; T J Mitchison
Journal: Nature Date: 1992-10-08 Impact factor: 49.962

4. Allosteric inhibition of kinesin-5 modulates its processive directional motility.

Authors: Benjamin H Kwok; Lukas C Kapitein; Jeffrey H Kim; Erwin J G Peterman; Christoph F Schmidt; Tarun M Kapoor
Journal: Nat Chem Biol Date: 2006-08-06 Impact factor: 15.040

5. The polarity and dynamics of microtubule assembly in the budding yeast Saccharomyces cerevisiae.

Authors: P S Maddox; K S Bloom; E D Salmon
Journal: Nat Cell Biol Date: 2000-01 Impact factor: 28.824

6. The Caenorhabditis elegans Aurora B kinase AIR-2 phosphorylates and is required for the localization of a BimC kinesin to meiotic and mitotic spindles.

Authors: John D Bishop; Zhenbo Han; Jill M Schumacher
Journal: Mol Biol Cell Date: 2004-11-17 Impact factor: 4.138

7. Kinetochore microtubule dynamics and the metaphase-anaphase transition.

Authors: Y Zhai; P J Kronebusch; G G Borisy
Journal: J Cell Biol Date: 1995-11 Impact factor: 10.539

8. Cytoplasmic dynein is required for the nuclear attachment and migration of centrosomes during mitosis in Drosophila.

Authors: J T Robinson; E J Wojcik; M A Sanders; M McGrail; T S Hays
Journal: J Cell Biol Date: 1999-08-09 Impact factor: 10.539

9. The kinesin Eg5 drives poleward microtubule flux in Xenopus laevis egg extract spindles.

Authors: David T Miyamoto; Zachary E Perlman; Kendra S Burbank; Aaron C Groen; Timothy J Mitchison
Journal: J Cell Biol Date: 2004-12-06 Impact factor: 10.539

10. Dynein/dynactin regulate metaphase spindle length by targeting depolymerizing activities to spindle poles.

Authors: Jedidiah Gaetz; Tarun M Kapoor
Journal: J Cell Biol Date: 2004-08-16 Impact factor: 10.539

73 in total

1. Elk-1 interacts with dynein upon serum stimulation but independent of serine 383 phosphorylation.

Authors: Ozlem Demir; Oya Ari; Isil Aksan Kurnaz
Journal: Cell Mol Neurobiol Date: 2011-09-21 Impact factor: 5.046

Review 2. Unconventional functions of microtubule motors.

Authors: Virgil Muresan; Zoia Muresan
Journal: Arch Biochem Biophys Date: 2012-01-28 Impact factor: 4.013

3. Mad1 promotes chromosome congression by anchoring a kinesin motor to the kinetochore.

Authors: Takashi Akera; Yuhei Goto; Masamitsu Sato; Masayuki Yamamoto; Yoshinori Watanabe
Journal: Nat Cell Biol Date: 2015-08-10 Impact factor: 28.824

Review 4. The spindle assembly checkpoint promotes chromosome bi-orientation: A novel Mad1 role in chromosome alignment.

Authors: Takashi Akera; Yoshinori Watanabe
Journal: Cell Cycle Date: 2016 Impact factor: 4.534

5. Loop L5 assumes three distinct orientations during the ATPase cycle of the mitotic kinesin Eg5: a transient and time-resolved fluorescence study.

Authors: Joseph M Muretta; William M Behnke-Parks; Jennifer Major; Karl J Petersen; Adeline Goulet; Carolyn A Moores; David D Thomas; Steven S Rosenfeld
Journal: J Biol Chem Date: 2013-10-21 Impact factor: 5.157

6. Kinesin-12, a mitotic microtubule-associated motor protein, impacts axonal growth, navigation, and branching.

Authors: Mei Liu; Vidya C Nadar; Frank Kozielski; Marta Kozlowska; Wenqian Yu; Peter W Baas
Journal: J Neurosci Date: 2010-11-03 Impact factor: 6.167

7. KIF11 as a Potential Marker of Spermatogenesis Within Mouse Seminiferous Tubule Cross-sections.

Authors: Miki Hara-Yokoyama; Hidetake Kurihara; Shozo Ichinose; Hironori Matsuda; Shizuko Ichinose; Masaru Kurosawa; Norihiro Tada; Chihiro Iwahara; Kazue Terasawa; Katarzyna A Podyma-Inoue; Koichi Furukawa; Kazuhisa Iwabuchi
Journal: J Histochem Cytochem Date: 2019-08-19 Impact factor: 2.479