PURPOSE: Anemia is a common comorbidity in patients presenting with ST-elevation myocardial infarction (STEMI). The aim of this study was to investigate the in-hospital prognostic value of admission hemoglobin (Hb) levels in patients with acute STEMI undergoing primary percutaneous coronary intervention (p-PCI). METHODS: This is a retrospective study of 1,625 patients with STEMI stratified by quartiles of admission Hb concentration (Q1 ≤12.5 g/dl, Q2 12.6-13.8 g/dl, Q3 13.9-15.0 g/dl, Q4 ≥15.1 g/dl). Main outcome measures were in-hospital rates of all cause mortality, re-infarction, target vessel revascularization, stroke, heart failure (HF) and bleeding complications. RESULTS: The incidences of in-hospital mortality according to quartiles from Q1 to Q4 were 8.6, 3.9, 2.4 and 2.6%, respectively (p < 0.001). The incidences of major hemorrhage and HF were significantly higher in Q1, compared to the other quartiles (7.4, 1.9, 3.1, 2.8%, p < 0.001; 16.3, 8.5, 7.7, 9.8%, p < 0.001, respectively). Multiple logistic-regression analysis showed that low admission Hb level (Q1) is an independent and a potent predictor for in-hospital mortality [unadjusted odds ratio (OR): 3.84, 95% confidence interval (CI): 1.78-7.82; p < 0.001]. CONCLUSION: Lower concentrations of Hb on admission are associated with higher rates of in-hospital mortality, heart failure and major bleeding after p-PCI.
PURPOSE:Anemia is a common comorbidity in patients presenting with ST-elevation myocardial infarction (STEMI). The aim of this study was to investigate the in-hospital prognostic value of admission hemoglobin (Hb) levels in patients with acute STEMI undergoing primary percutaneous coronary intervention (p-PCI). METHODS: This is a retrospective study of 1,625 patients with STEMI stratified by quartiles of admission Hb concentration (Q1 ≤12.5 g/dl, Q2 12.6-13.8 g/dl, Q3 13.9-15.0 g/dl, Q4 ≥15.1 g/dl). Main outcome measures were in-hospital rates of all cause mortality, re-infarction, target vessel revascularization, stroke, heart failure (HF) and bleeding complications. RESULTS: The incidences of in-hospital mortality according to quartiles from Q1 to Q4 were 8.6, 3.9, 2.4 and 2.6%, respectively (p < 0.001). The incidences of major hemorrhage and HF were significantly higher in Q1, compared to the other quartiles (7.4, 1.9, 3.1, 2.8%, p < 0.001; 16.3, 8.5, 7.7, 9.8%, p < 0.001, respectively). Multiple logistic-regression analysis showed that low admission Hb level (Q1) is an independent and a potent predictor for in-hospital mortality [unadjusted odds ratio (OR): 3.84, 95% confidence interval (CI): 1.78-7.82; p < 0.001]. CONCLUSION: Lower concentrations of Hb on admission are associated with higher rates of in-hospital mortality, heart failure and major bleeding after p-PCI.
Authors: Tamara B Horwich; Gregg C Fonarow; Michele A Hamilton; W Robb MacLellan; Jeff Borenstein Journal: J Am Coll Cardiol Date: 2002-06-05 Impact factor: 24.094
Authors: R Andrew Archbold; Dauda Balami; Abdul Al-Hajiri; Abdel Suliman; Reg Liew; Jackie Cooper; Kulasegarum Ranjadayalan; Charles J Knight; Andrew Deaner; Adam D Timmis Journal: Am Heart J Date: 2006-12 Impact factor: 4.749
Authors: Colleen Gorman Koch; Liang Li; Daniel I Sessler; Priscilla Figueroa; Gerald A Hoeltge; Tomislav Mihaljevic; Eugene H Blackstone Journal: N Engl J Med Date: 2008-03-20 Impact factor: 91.245
Authors: Eugenia Nikolsky; Eve D Aymong; Amir Halkin; Cindy L Grines; David A Cox; Eulogio Garcia; Roxana Mehran; James E Tcheng; John J Griffin; Giulio Guagliumi; Thomas Stuckey; Mark Turco; David A Cohen; Manuela Negoita; Alexandra J Lansky; Gregg W Stone Journal: J Am Coll Cardiol Date: 2004-08-04 Impact factor: 24.094
Authors: Rakesh Sharma; Darrel P Francis; Bertram Pitt; Philip A Poole-Wilson; Andrew J S Coats; Stefan D Anker Journal: Eur Heart J Date: 2004-06 Impact factor: 29.983
Authors: Jean-Pierre Bassand; Rizwan Afzal; John Eikelboom; Lars Wallentin; Ron Peters; Andrzej Budaj; Keith A A Fox; Campbell D Joyner; Susan Chrolavicius; Christopher B Granger; Shamir Mehta; Salim Yusuf Journal: Eur Heart J Date: 2009-10-12 Impact factor: 29.983
Authors: Lennaert Kleijn; B Daan Westenbrink; Vincent M van Deursen; Kevin Damman; Rudolf A de Boer; Hans L Hillege; Dirk J van Veldhuisen; Adriaan A Voors; Peter van der Meer Journal: Clin Res Cardiol Date: 2014-02-08 Impact factor: 5.460
Authors: Eva S Kehmeier; Wolfgang Lepper; Martina Kropp; Christian Heiss; Ulrike Hendgen-Cotta; Jan Balzer; Mirja Neizel; Christian Meyer; Marc W Merx; Pablo E Verde; Christian Ohmann; Gerd Heusch; Malte Kelm; Tienush Rassaf Journal: Clin Res Cardiol Date: 2012-05-06 Impact factor: 5.460
Authors: Jens Wiebe; Helge Möllmann; Astrid Most; Oliver Dörr; Kay Weipert; Johannes Rixe; Christoph Liebetrau; Albrecht Elsässer; Stephan Achenbach; Christian Hamm; Holger Nef Journal: Clin Res Cardiol Date: 2013-10-18 Impact factor: 5.460
Authors: Marja Puurunen; Tuomas Kiviniemi; Wail Nammas; Axel Schlitt; Andrea Rubboli; Kai Nyman; Pasi Karjalainen; Paulus Kirchhof; Gregory Y H Lip; Juhani K E Airaksinen Journal: BMJ Open Date: 2014-05-13 Impact factor: 2.692