Literature DB >> 21930786

Functional elements in initiation factors 1, 1A, and 2β discriminate against poor AUG context and non-AUG start codons.

Pilar Martin-Marcos1, Yuen-Nei Cheung, Alan G Hinnebusch.   

Abstract

Yeast eIF1 inhibits initiation at non-AUG triplets, but it was unknown whether it also discriminates against AUGs in suboptimal context. As in other eukaryotes, the yeast gene encoding eIF1 (SUI1) contains an AUG in poor context, which could underlie translational autoregulation. Previously, eIF1 mutations were identified that increase initiation at UUG codons (Sui(-) phenotype), and we obtained mutations with the opposite phenotype of suppressing UUG initiation (Ssu(-) phenotype). Remarkably, Sui(-) mutations in eukaryotic translation initiation factor 1 (eIF1), eIF1A, and eIF2β all increase SUI1 expression in a manner diminished by introducing the optimal context at the SUI1 AUG, whereas Ssu(-) mutations in eIF1 and eIF1A decrease SUI1 expression with the native, but not optimal, context present. Therefore, discrimination against weak context depends on specific residues in eIFs 1, 1A, and 2β that also impede selection of non-AUGs, suggesting that context nucleotides and AUG act coordinately to stabilize the preinitiation complex. Although eIF1 autoregulates by discriminating against poor context in yeast and mammals, this mechanism does not prevent eIF1 overproduction in yeast, accounting for the hyperaccuracy phenotype afforded by SUI1 overexpression.

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Year:  2011        PMID: 21930786      PMCID: PMC3232919          DOI: 10.1128/MCB.05819-11

Source DB:  PubMed          Journal:  Mol Cell Biol        ISSN: 0270-7306            Impact factor:   4.272


  47 in total

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2.  Genome-wide analysis of mRNAs regulated by the nonsense-mediated and 5' to 3' mRNA decay pathways in yeast.

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4.  The roles of individual eukaryotic translation initiation factors in ribosomal scanning and initiation codon selection.

Authors:  Tatyana V Pestova; Victoria G Kolupaeva
Journal:  Genes Dev       Date:  2002-11-15       Impact factor: 11.361

5.  Interactions of eukaryotic translation initiation factor 3 (eIF3) subunit NIP1/c with eIF1 and eIF5 promote preinitiation complex assembly and regulate start codon selection.

Authors:  Leos Valásek; Klaus H Nielsen; Fan Zhang; Christie A Fekete; Alan G Hinnebusch
Journal:  Mol Cell Biol       Date:  2004-11       Impact factor: 4.272

6.  Import of proteins into mitochondria. Yeast cells grown in the presence of carbonyl cyanide m-chlorophenylhydrazone accumulate massive amounts of some mitochondrial precursor polypeptides.

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Journal:  J Biol Chem       Date:  1982-11-10       Impact factor: 5.157

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8.  Position of eukaryotic initiation factor eIF1 on the 40S ribosomal subunit determined by directed hydroxyl radical probing.

Authors:  Ivan B Lomakin; Victoria G Kolupaeva; Assen Marintchev; Gerhard Wagner; Tatyana V Pestova
Journal:  Genes Dev       Date:  2003-11-04       Impact factor: 11.361

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Authors:  Svetlana A Shabalina; Aleksey Y Ogurtsov; Igor B Rogozin; Eugene V Koonin; David J Lipman
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  47 in total

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Journal:  Nat Struct Mol Biol       Date:  2012-06-05       Impact factor: 15.369

2.  Interaction between 25S rRNA A loop and eukaryotic translation initiation factor 5B promotes subunit joining and ensures stringent AUG selection.

Authors:  Hiroyuki Hiraishi; Byung-Sik Shin; Tsuyoshi Udagawa; Naoki Nemoto; Wasimul Chowdhury; Jymie Graham; Christian Cox; Megan Reid; Susan J Brown; Katsura Asano
Journal:  Mol Cell Biol       Date:  2013-07-08       Impact factor: 4.272

3.  β-Hairpin loop of eukaryotic initiation factor 1 (eIF1) mediates 40 S ribosome binding to regulate initiator tRNA(Met) recruitment and accuracy of AUG selection in vivo.

Authors:  Pilar Martin-Marcos; Jagpreet Nanda; Rafael E Luna; Gerhard Wagner; Jon R Lorsch; Alan G Hinnebusch
Journal:  J Biol Chem       Date:  2013-07-26       Impact factor: 5.157

4.  Human eIF5 and eIF1A Compete for Binding to eIF5B.

Authors:  Kai Ying Lin; Nabanita Nag; Tatyana V Pestova; Assen Marintchev
Journal:  Biochemistry       Date:  2018-09-26       Impact factor: 3.162

5.  Tma64/eIF2D, Tma20/MCT-1, and Tma22/DENR Recycle Post-termination 40S Subunits In Vivo.

Authors:  David J Young; Desislava S Makeeva; Fan Zhang; Aleksandra S Anisimova; Elena A Stolboushkina; Fardin Ghobakhlou; Ivan N Shatsky; Sergey E Dmitriev; Alan G Hinnebusch; Nicholas R Guydosh
Journal:  Mol Cell       Date:  2018-08-23       Impact factor: 17.970

6.  The C-terminal domain of eukaryotic initiation factor 5 promotes start codon recognition by its dynamic interplay with eIF1 and eIF2β.

Authors:  Rafael E Luna; Haribabu Arthanari; Hiroyuki Hiraishi; Jagpreet Nanda; Pilar Martin-Marcos; Michelle A Markus; Barak Akabayov; Alexander G Milbradt; Lunet E Luna; Hee-Chan Seo; Sven G Hyberts; Amr Fahmy; Mikhail Reibarkh; David Miles; Patrick R Hagner; Elizabeth M O'Day; Tingfang Yi; Assen Marintchev; Alan G Hinnebusch; Jon R Lorsch; Katsura Asano; Gerhard Wagner
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7.  Quantitative global studies reveal differential translational control by start codon context across the fungal kingdom.

Authors:  Edward W J Wallace; Corinne Maufrais; Jade Sales-Lee; Laura R Tuck; Luciana de Oliveira; Frank Feuerbach; Frédérique Moyrand; Prashanthi Natarajan; Hiten D Madhani; Guilhem Janbon
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8.  Coordinated movements of eukaryotic translation initiation factors eIF1, eIF1A, and eIF5 trigger phosphate release from eIF2 in response to start codon recognition by the ribosomal preinitiation complex.

Authors:  Jagpreet S Nanda; Adesh K Saini; Antonio M Muñoz; Alan G Hinnebusch; Jon R Lorsch
Journal:  J Biol Chem       Date:  2013-01-04       Impact factor: 5.157

9.  The interaction between eukaryotic initiation factor 1A and eIF5 retains eIF1 within scanning preinitiation complexes.

Authors:  Rafael E Luna; Haribabu Arthanari; Hiroyuki Hiraishi; Barak Akabayov; Leiming Tang; Christian Cox; Michelle A Markus; Lunet E Luna; Yuka Ikeda; Ryosuke Watanabe; Edward Bedoya; Cathy Yu; Shums Alikhan; Gerhard Wagner; Katsura Asano
Journal:  Biochemistry       Date:  2013-12-19       Impact factor: 3.162

10.  Autoantibody response to Sui1 and its tissue-specific expression in hepatocellular carcinoma.

Authors:  Jian-Wei Zhou; Yuan Li; Li-Xia Yue; Cheng-Lin Luo; Yao Chen; Jian-Ying Zhang
Journal:  Tumour Biol       Date:  2015-09-19
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