| Literature DB >> 21929033 |
Víctor M Pérez-García1, Gabriel F Calvo, Juan Belmonte-Beitia, David Diego, Luis Pérez-Romasanta.
Abstract
We put forward a nonlinear wave model describing the fundamental dynamical features of an aggressive type of brain tumors. Our model accounts for the invasion of normal tissue by a proliferating and propagating rim of active glioma cancer cells in the tumor boundary and the subsequent formation of a necrotic core. By resorting to numerical simulations, phase space analysis, and exact solutions we prove that bright solitary tumor waves develop in such systems. Possible implications of our model as a tool to extract relevant patient specific tumor parameters in combination with standard preoperative clinical imaging are also discussed.Entities:
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Year: 2011 PMID: 21929033 DOI: 10.1103/PhysRevE.84.021921
Source DB: PubMed Journal: Phys Rev E Stat Nonlin Soft Matter Phys ISSN: 1539-3755