OBJECT: Knowledge of the total circulating blood volume (TCBV) is essential for the treatment of a variety of medical conditions and blood disorders. To date, blood volume analysis is rarely carried out due to the disadvantages of available methods. Our aim was to develop a widely available, simple, fast, yet accurate method for the determination of the total circulating blood volume. MATERIALS AND METHODS: Magnetic resonance (MR) is a well-established, non-invasive technique. In this article, we present a method that uses MR contrast agents for the determination of the blood volume. The dependence of MR relaxation times on the concentration of MR contrast agents allows the calculation of the volume the contrast agent has been diluted in. RESULTS: In phantom and in vivo experiments we could demonstrate that TCBV can be determined with high accuracy and precision. CONCLUSION: This work introduces a novel method for the determination of the total circulating blood volume using magnetic resonance contrast agents as tracers.
OBJECT: Knowledge of the total circulating blood volume (TCBV) is essential for the treatment of a variety of medical conditions and blood disorders. To date, blood volume analysis is rarely carried out due to the disadvantages of available methods. Our aim was to develop a widely available, simple, fast, yet accurate method for the determination of the total circulating blood volume. MATERIALS AND METHODS: Magnetic resonance (MR) is a well-established, non-invasive technique. In this article, we present a method that uses MR contrast agents for the determination of the blood volume. The dependence of MR relaxation times on the concentration of MR contrast agents allows the calculation of the volume the contrast agent has been diluted in. RESULTS: In phantom and in vivo experiments we could demonstrate that TCBV can be determined with high accuracy and precision. CONCLUSION: This work introduces a novel method for the determination of the total circulating blood volume using magnetic resonance contrast agents as tracers.
Authors: Peter Caravan; Normand J Cloutier; Matthew T Greenfield; Sarah A McDermid; Stephen U Dunham; Jeff W M Bulte; John C Amedio; Richard J Looby; Ronald M Supkowski; William DeW Horrocks; Thomas J McMurry; Randall B Lauffer Journal: J Am Chem Soc Date: 2002-03-27 Impact factor: 15.419
Authors: T C Pearson; D L Guthrie; J Simpson; S Chinn; G Barosi; A Ferrant; S M Lewis; Y Najean Journal: Br J Haematol Date: 1995-04 Impact factor: 6.998
Authors: Ana-Silvia Androne; Stuart D Katz; Lars Lund; John LaManca; Alhakam Hudaihed; Katarzyna Hryniewicz; Donna M Mancini Journal: Circulation Date: 2003-01-21 Impact factor: 29.690
Authors: Rajiv Ramasawmy; Toby Rogers; Miguel A Alcantar; Delaney R McGuirt; Jaffar M Khan; Peter Kellman; Hui Xue; Anthony Z Faranesh; Adrienne E Campbell-Washburn; Robert J Lederman; Daniel A Herzka Journal: J Cardiovasc Magn Reson Date: 2018-09-10 Impact factor: 5.364