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Literature DB >> 21922183

The inflammatory tumor microenvironment, epithelial mesenchymal transition and lung carcinogenesis.

Eileen L Heinrich¹, Tonya C Walser, Kostyantyn Krysan, Elvira L Liclican, Jeanette L Grant, Nicole L Rodriguez, Steven M Dubinett.

Abstract

The inflammatory tumor microenvironment (TME) has many roles in tumor progression and metastasis, including creation of a hypoxic environment, increased angiogenesis and invasion, changes in expression of microRNAs (miRNAs) and an increase in a stem cell phenotype. Each of these has an impact on epithelial mesenchymal transition (EMT), particularly through the downregulation of E-cadherin. Here we review seminal work and recent findings linking the role of inflammation in the TME, EMT and lung cancer initiation, progression and metastasis. Finally, we discuss the potential of targeting aspects of inflammation and EMT in cancer prevention and treatment.

Entities: Disease Gene

Year: 2011 PMID： 21922183 PMCID： PMC3343201 DOI： 10.1007/s12307-011-0089-0

Source DB: PubMed Journal: Cancer Microenviron ISSN： 1875-2284

162 in total

Review 1. MicroRNAs: small RNAs with a big role in gene regulation.

Authors: Lin He; Gregory J Hannon
Journal: Nat Rev Genet Date: 2004-07 Impact factor: 53.242

2. DCAMKL-1 regulates epithelial-mesenchymal transition in human pancreatic cells through a miR-200a-dependent mechanism.

Authors: Sripathi M Sureban; Randal May; Stan A Lightfoot; Aimee B Hoskins; Megan Lerner; Daniel J Brackett; Russell G Postier; Rama Ramanujam; Altaf Mohammed; Chinthalapally V Rao; James H Wyche; Shrikant Anant; Courtney W Houchen
Journal: Cancer Res Date: 2011-02-01 Impact factor: 12.701

3. Basement membrane matrix modifies cytokine interactions between lung cancer cells and fibroblasts.

Authors: Takumi Akashi; Junko Minami; Yuki Ishige; Yoshinobu Eishi; Touichiro Takizawa; Morio Koike; Masaki Yanagishita
Journal: Pathobiology Date: 2005 Impact factor: 4.342

4. Non-small cell lung cancer cyclooxygenase-2-dependent invasion is mediated by CD44.

Authors: M Dohadwala; J Luo; L Zhu; Y Lin; G J Dougherty; S Sharma; M Huang; M Pold; R K Batra; S M Dubinett
Journal: J Biol Chem Date: 2001-04-24 Impact factor: 5.157

5. p53-dependent regulation of growth, epithelial-mesenchymal transition and stemness in normal pancreatic epithelial cells.

Authors: Andreia V Pinho; Ilse Rooman; Francisco X Real
Journal: Cell Cycle Date: 2011-04-15 Impact factor: 4.534

Review 6. Inflammation, epithelial to mesenchymal transition, and epidermal growth factor receptor tyrosine kinase inhibitor resistance.

Authors: Kostyantyn Krysan; Jay M Lee; Mariam Dohadwala; Brian K Gardner; Karen L Reckamp; Edward Garon; Maie St John; Sherven Sharma; Steven M Dubinett
Journal: J Thorac Oncol Date: 2008-02 Impact factor: 15.609

7. Loss of the tight junction protein claudin-7 correlates with histological grade in both ductal carcinoma in situ and invasive ductal carcinoma of the breast.

Authors: Scott L Kominsky; Pedram Argani; Dorian Korz; Ella Evron; Venu Raman; Elizabeth Garrett; Alan Rein; Guido Sauter; Olli-P Kallioniemi; Saraswati Sukumar
Journal: Oncogene Date: 2003-04-03 Impact factor: 9.867

Review 8. A small piece in the cancer puzzle: microRNAs as tumor suppressors and oncogenes.

Authors: O A Kent; J T Mendell
Journal: Oncogene Date: 2006-10-09 Impact factor: 9.867

9. Enhanced expression of SPARC/osteonectin in the tumor-associated stroma of non-small cell lung cancer is correlated with markers of hypoxia/acidity and with poor prognosis of patients.

Authors: Michael I Koukourakis; Alexandra Giatromanolaki; Rolf A Brekken; Efthimios Sivridis; Kevin C Gatter; Adrian L Harris; E Helene Sage
Journal: Cancer Res Date: 2003-09-01 Impact factor: 12.701

Review 10. Evidence for self-renewing lung cancer stem cells and their implications in tumor initiation, progression, and targeted therapy.

Authors: James P Sullivan; John D Minna; Jerry W Shay
Journal: Cancer Metastasis Rev Date: 2010-03 Impact factor: 9.264

31 in total

1. Hair follicle disruption facilitates pathogenesis to UVB-induced cutaneous inflammation and basal cell carcinoma development in Ptch(+/-) mice.

Authors: Jianmin Xu; Zhiping Weng; Aadithya Arumugam; Xiuwei Tang; Sandeep C Chaudhary; Changzhao Li; Angela M Christiano; Craig A Elmets; David R Bickers; Mohammad Athar
Journal: Am J Pathol Date: 2014-03-12 Impact factor: 4.307

2. Identification of shared and unique susceptibility pathways among cancers of the lung, breast, and prostate from genome-wide association studies and tissue-specific protein interactions.

Authors: David C Qian; Jinyoung Byun; Younghun Han; Casey S Greene; John K Field; Rayjean J Hung; Yonathan Brhane; John R Mclaughlin; Gordon Fehringer; Maria Teresa Landi; Albert Rosenberger; Heike Bickeböller; Jyoti Malhotra; Angela Risch; Joachim Heinrich; David J Hunter; Brian E Henderson; Christopher A Haiman; Fredrick R Schumacher; Rosalind A Eeles; Douglas F Easton; Daniela Seminara; Christopher I Amos
Journal: Hum Mol Genet Date: 2015-10-19 Impact factor: 6.150

The inflammatory tumor microenvironment, epithelial mesenchymal transition and lung carcinogenesis.

Review 1. MicroRNAs: small RNAs with a big role in gene regulation.

2. DCAMKL-1 regulates epithelial-mesenchymal transition in human pancreatic cells through a miR-200a-dependent mechanism.

3. Basement membrane matrix modifies cytokine interactions between lung cancer cells and fibroblasts.

4. Non-small cell lung cancer cyclooxygenase-2-dependent invasion is mediated by CD44.

5. p53-dependent regulation of growth, epithelial-mesenchymal transition and stemness in normal pancreatic epithelial cells.

Review 6. Inflammation, epithelial to mesenchymal transition, and epidermal growth factor receptor tyrosine kinase inhibitor resistance.

7. Loss of the tight junction protein claudin-7 correlates with histological grade in both ductal carcinoma in situ and invasive ductal carcinoma of the breast.

Review 8. A small piece in the cancer puzzle: microRNAs as tumor suppressors and oncogenes.

9. Enhanced expression of SPARC/osteonectin in the tumor-associated stroma of non-small cell lung cancer is correlated with markers of hypoxia/acidity and with poor prognosis of patients.

Review 10. Evidence for self-renewing lung cancer stem cells and their implications in tumor initiation, progression, and targeted therapy.

1. Hair follicle disruption facilitates pathogenesis to UVB-induced cutaneous inflammation and basal cell carcinoma development in Ptch(+/-) mice.

2. Identification of shared and unique susceptibility pathways among cancers of the lung, breast, and prostate from genome-wide association studies and tissue-specific protein interactions.

3. A novel molecular pathway for Snail-dependent, SPARC-mediated invasion in non-small cell lung cancer pathogenesis.

Review 4. Leveraging self-assembled nanobiomaterials for improved cancer immunotherapy.

5. Resolvin E1 Reduces Tumor Growth in a Xenograft Model of Lung Cancer.

6. Novel compound 1,3-bis (3,5-dichlorophenyl) urea inhibits lung cancer progression.

Review 7. TGF-β/SMAD Pathway and Its Regulation in Hepatic Fibrosis.

Review 8. Cancer overdiagnosis: a biological challenge and clinical dilemma.

Review 9. The Role of Tumor Inflammatory Microenvironment in Lung Cancer.

10. The role of chronic inflammation in obesity-associated cancers.