BACKGROUND: Some epidemiologic studies suggest that maternal consumption of cured meat during pregnancy may increase risk of brain tumors in offspring. We explored whether this possible association was modified by fetal genetic polymorphisms in genes coding for glutathione S-transferases (GSTs) that may inactivate nitroso compounds. METHODS: We assessed six GST variants: GSTM1 null, GSTT1 null, GSTP1(I105V) (rs1695), GSTP1(A114V) (rs1138272), GSTM3*B (3-bp deletion), and GSTM3(A-63C) (rs1332018) within a population-based case-control study with data on maternal prenatal cured meat consumption (202 cases and 286 controls born in California or Washington, 1978-1990). RESULTS: Risk of childhood brain tumor increased with increasing cured meat intake by the mother during pregnancy among children without GSTT1 [OR = 1.29; 95% confidence interval (95% CI), 1.07-1.57 for each increase in the frequency of consumption per week] or with potentially reduced GSTM3 (any -63C allele; OR = 1.14; 95% CI, 1.03-1.26), whereas no increased risk was observed among those with GSTT1 or presumably normal GSTM3 levels (interaction P = 0.01 for each). CONCLUSIONS: Fetal ability to deactivate nitrosoureas may modify the association between childhood brain tumors and maternal prenatal consumption of cured meats. IMPACT: These results support the hypothesis that maternal avoidance during pregnancy of sources of some nitroso compounds or their precursors may reduce risk of brain tumors in some children.
BACKGROUND: Some epidemiologic studies suggest that maternal consumption of cured meat during pregnancy may increase risk of brain tumors in offspring. We explored whether this possible association was modified by fetal genetic polymorphisms in genes coding for glutathione S-transferases (GSTs) that may inactivate nitroso compounds. METHODS: We assessed six GST variants: GSTM1 null, GSTT1 null, GSTP1(I105V) (rs1695), GSTP1(A114V) (rs1138272), GSTM3*B (3-bp deletion), and GSTM3(A-63C) (rs1332018) within a population-based case-control study with data on maternal prenatal cured meat consumption (202 cases and 286 controls born in California or Washington, 1978-1990). RESULTS: Risk of childhood brain tumor increased with increasing cured meat intake by the mother during pregnancy among children without GSTT1 [OR = 1.29; 95% confidence interval (95% CI), 1.07-1.57 for each increase in the frequency of consumption per week] or with potentially reduced GSTM3 (any -63C allele; OR = 1.14; 95% CI, 1.03-1.26), whereas no increased risk was observed among those with GSTT1 or presumably normal GSTM3 levels (interaction P = 0.01 for each). CONCLUSIONS: Fetal ability to deactivate nitrosoureas may modify the association between childhood brain tumors and maternal prenatal consumption of cured meats. IMPACT: These results support the hypothesis that maternal avoidance during pregnancy of sources of some nitroso compounds or their precursors may reduce risk of brain tumors in some children.
Authors: A Inskip; J Elexperu-Camiruaga; N Buxton; P S Dias; J MacIntosh; D Campbell; P W Jones; L Yengi; J A Talbot; R C Strange Journal: Biochem J Date: 1995-12-15 Impact factor: 3.857
Authors: S Preston-Martin; J M Pogoda; B A Mueller; E A Holly; W Lijinsky; R L Davis Journal: Cancer Epidemiol Biomarkers Prev Date: 1996-08 Impact factor: 4.254
Authors: Philip J Lupo; Darryl Nousome; M Fatih Okcu; Murali Chintagumpala; Michael E Scheurer Journal: Pediatr Hematol Oncol Date: 2012-09-20 Impact factor: 1.969
Authors: Ivo S Muskens; Chenan Zhang; Adam J de Smith; Jaclyn A Biegel; Kyle M Walsh; Joseph L Wiemels Journal: Neuro Oncol Date: 2019-11-04 Impact factor: 12.300
Authors: Kimberly J Johnson; Jennifer Cullen; Jill S Barnholtz-Sloan; Quinn T Ostrom; Chelsea E Langer; Michelle C Turner; Roberta McKean-Cowdin; James L Fisher; Philip J Lupo; Sonia Partap; Judith A Schwartzbaum; Michael E Scheurer Journal: Cancer Epidemiol Biomarkers Prev Date: 2014-09-05 Impact factor: 4.254
Authors: Anna M Dahlin; Mads V Hollegaard; Carl Wibom; Ulrika Andersson; David M Hougaard; Isabelle Deltour; Ulf Hjalmars; Beatrice Melin Journal: J Neurooncol Date: 2015-08-20 Impact factor: 4.130
Authors: Jessica L Barrington-Trimis; Susan Searles Nielsen; Susan Preston-Martin; W James Gauderman; Elizabeth A Holly; Federico M Farin; Beth A Mueller; Roberta McKean-Cowdin Journal: PLoS One Date: 2013-11-18 Impact factor: 3.240
Authors: Ondine S von Ehrenstein; Julia E Heck; Andrew S Park; Myles Cockburn; Loraine Escobedo; Beate Ritz Journal: Environ Health Perspect Date: 2015-10-27 Impact factor: 9.031