Arsenic speciation in biomedical sciences: recent advances and applications.

Speciation analysis of trace elements is an important issue in biomedical and toxicological sciences because different elemental species have different effects on health and the environment. For humans, arsenic (As) is a toxic element; the toxicity of As compounds is highly dependent on its chemical form. Although inorganic As compounds are human carcinogens, organic arsenicals are relatively less toxic. This article deals with recent advances and applications of methods for As speciation in biomedical sciences, with emphasis on the specimens commonly encountered in biomedical laboratories.