Literature DB >> 21910990

Emodepside and SL0-1 potassium channels: a review.

R J Martin1, S K Buxton, C Neveu, C L Charvet, A P Robertson.   

Abstract

Nematode parasites infect humans and domestic animals; treatment and prophylaxis require anthelmintic drugs because vaccination and sanitation is limited. Emodepside is a more recently introduced cyclooctadepsipeptide drug that has actions against GI nematodes, lungworm, and microfilaria. It has a novel mode of action which breaks resistance to the classical anthelmintics (benzimidazoles, macrocyclic lactones and cholinergic agonists). Here we review studies on its mode of action which suggest that it acts to inhibit neuronal and muscle activity of nematodes by increasing the opening of calcium-activated potassium (SLO-1) channels.
Copyright © 2011 Elsevier Inc. All rights reserved.

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Year:  2011        PMID： 21910990      PMCID： PMC3262936          DOI： 10.1016/j.exppara.2011.08.012

Source DB:  PubMed          Journal:  Exp Parasitol        ISSN： 0014-4894            Impact factor:   2.011


  39 in total

1.  Simultaneous binding of two protein kinases to a calcium-dependent potassium channel.

Authors:  J Wang; Y Zhou; H Wen; I B Levitan
Journal:  J Neurosci       Date:  1999-05-15       Impact factor: 6.167

2.  Latrophilin-like receptor from the parasitic nematode Haemonchus contortus as target for the anthelmintic depsipeptide PF1022A.

Authors:  B Saeger; H P Schmitt-Wrede; M Dehnhardt; W P Benten; J Krücken; A Harder; G Von Samson-Himmelstjerna; H Wiegand; F Wunderlich
Journal:  FASEB J       Date:  2001-05       Impact factor: 5.191

3.  Circadian regulation of gene expression systems in the Drosophila head.

Authors:  A Claridge-Chang; H Wijnen; F Naef; C Boothroyd; N Rajewsky; M W Young
Journal:  Neuron       Date:  2001-11-20       Impact factor: 17.173

4.  Characterization of glutamate-gated chloride channels in the pharynx of wild-type and mutant Caenorhabditis elegans delineates the role of the subunit GluCl-alpha2 in the function of the native receptor.

Authors:  D J Pemberton; C J Franks; R J Walker; L Holden-Dye
Journal:  Mol Pharmacol       Date:  2001-05       Impact factor: 4.436

5.  SLO-1 potassium channels control quantal content of neurotransmitter release at the C. elegans neuromuscular junction.

Authors:  Z W Wang; O Saifee; M L Nonet; L Salkoff
Journal:  Neuron       Date:  2001-12-06       Impact factor: 17.173

6.  Characterization of K(+) currents using an in situ patch clamp technique in body wall muscle cells from Caenorhabditis elegans.

Authors:  Maëlle Jospin; Marie-Christine Mariol; Laurent Ségalat; Bruno Allard
Journal:  J Physiol       Date:  2002-10-15       Impact factor: 5.182

7.  Identification and characterization of a putative C. elegans potassium channel gene (Ce-slo-2) distantly related to Ca(2+)-activated K(+) channels.

Authors:  H H Lim; B J Park; H S Choi; C S Park; S H Eom; J Ahnn
Journal:  Gene       Date:  1999-11-15       Impact factor: 3.688

8.  The effect of the anthelmintic emodepside at the neuromuscular junction of the parasitic nematode Ascaris suum.

Authors:  J Willson; K Amliwala; A Harder; L Holden-Dye; R J Walker
Journal:  Parasitology       Date:  2003-01       Impact factor: 3.234

9.  A nematode FMRFamide-like peptide, SDPNFLRFamide (PF1), relaxes the dorsal muscle strip preparation of Ascaris suum.

Authors:  C J Franks; L Holden-Dye; R G Williams; F Y Pang; R J Walker
Journal:  Parasitology       Date:  1994-02       Impact factor: 3.234

Review 10.  Cyclooctadepsipeptides--an anthelmintically active class of compounds exhibiting a novel mode of action.

Authors:  Achim Harder; Hans-Peter Schmitt-Wrede; Jürgen Krücken; Predrag Marinovski; Frank Wunderlich; James Willson; Kiran Amliwala; Lindy Holden-Dye; Robert Walker
Journal:  Int J Antimicrob Agents       Date:  2003-09       Impact factor: 5.283
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  16 in total

Review 1.  Monoaminergic signaling as a target for anthelmintic drug discovery: receptor conservation among the free-living and parasitic nematodes.

Authors:  Richard Komuniecki; Wen Jing Law; Aaron Jex; Peter Geldhof; John Gray; Bruce Bamber; Robin B Gasser
Journal:  Mol Biochem Parasitol       Date:  2012-02-11       Impact factor: 1.759

2.  Anthelmintics: The best way to predict the future is to create it.

Authors:  Richard J Martin; Saurabh Verma; Shivani Choudhary; Sudhanva Kashyap; Melanie Abongwa; Fudan Zheng; Alan P Robertson
Journal:  Vet Parasitol       Date:  2015-06-20       Impact factor: 2.738

3.  Ion channels and drug transporters as targets for anthelmintics.

Authors:  Robert M Greenberg
Journal:  Curr Clin Microbiol Rep       Date:  2014-12

4.  A BRIEF REVIEW ON THE MODE OF ACTION OF ANTINEMATODAL DRUGS.

Authors:  Melanie Abongwa; Richard J Martin; Alan P Robertson
Journal:  Acta Vet (Beogr)       Date:  2017-06-26       Impact factor: 0.800

5.  Identification of putative potassium channel homologues in pathogenic protozoa.

Authors:  David L Prole; Neil V Marrion
Journal:  PLoS One       Date:  2012-02-21       Impact factor: 3.240

6.  Expression of five acetylcholine receptor subunit genes in Brugia malayi adult worms.

Authors:  Ben-Wen Li; Amy C Rush; Gary J Weil
Journal:  Int J Parasitol Drugs Drug Resist       Date:  2015-06-23       Impact factor: 4.077

7.  Heterologous Expression in Remodeled C. elegans: A Platform for Monoaminergic Agonist Identification and Anthelmintic Screening.

Authors:  Wenjing Law; Leah M Wuescher; Amanda Ortega; Vera M Hapiak; Patricia R Komuniecki; Richard Komuniecki
Journal:  PLoS Pathog       Date:  2015-04-30       Impact factor: 6.823

8.  Characterization of the Ca2+-gated and voltage-dependent K+-channel Slo-1 of nematodes and its interaction with emodepside.

Authors:  Daniel Kulke; Georg von Samson-Himmelstjerna; Sandra M Miltsch; Adrian J Wolstenholme; Aaron R Jex; Robin B Gasser; Cristina Ballesteros; Timothy G Geary; Jennifer Keiser; Simon Townson; Achim Harder; Jürgen Krücken
Journal:  PLoS Negl Trop Dis       Date:  2014-12-18

Review 9.  Recent advances in candidate-gene and whole-genome approaches to the discovery of anthelmintic resistance markers and the description of drug/receptor interactions.

Authors:  Andrew C Kotze; Peter W Hunt; Philip Skuce; Georg von Samson-Himmelstjerna; Richard J Martin; Heinz Sager; Jürgen Krücken; Jane Hodgkinson; Anne Lespine; Aaron R Jex; John S Gilleard; Robin N Beech; Adrian J Wolstenholme; Janina Demeler; Alan P Robertson; Claude L Charvet; Cedric Neveu; Ronald Kaminsky; Lucien Rufener; Melanie Alberich; Cecile Menez; Roger K Prichard
Journal:  Int J Parasitol Drugs Drug Resist       Date:  2014-08-13       Impact factor: 4.077

10.  Diethylcarbamazine increases activation of voltage-activated potassium (SLO-1) currents in Ascaris suum and potentiates effects of emodepside.

Authors:  Samuel K Buxton; Alan P Robertson; Richard J Martin
Journal:  PLoS Negl Trop Dis       Date:  2014-11-20
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