PURPOSE: To investigate the prevalence and characteristics of primary angle-closure suspect (PACS), primary angle closure (PAC), and primary angle-closure glaucoma (PACG) in a rural population in China. METHODS: In all, 6716 Han Chinese 30 years of age and older (5480 subjects 40 years of age and older) from 13 villages in Handan were randomly selected and completed an ophthalmologic examination, including visual acuity, intraocular pressure (IOP), slit-lamp examination, gonioscopy and stereoscopic photography, and visual field. PACS was defined as present if either eye had the posterior trabecular meshwork not visible for 180° or more on gonioscopy. PAC was present in an eye with PACS and peripheral anterior synechiae (PAS) and/or IOP ≥ 21 mm Hg, but without glaucomatous neuropathy (GON). PACG was defined as PAC with evidence of GON. RESULTS: The standardized prevalences of PACG, PAC, and PACS were 0.5% (95% confidence interval [CI]: 0.3-0.7%), 1.5% (95% CI: 1.2-1.8%), and 10.4% (95% CI: 9.6-11.2%) in those 40 years of age and older. The prevalence of all three conditions increased with age (P < 0.001). Females had much higher rates of PACS, PAC, and PACG (P < 0.05); 21 persons with PACG (65%) were blind in at least one eye: 13 were due to glaucoma and the other 8 likely had other causes. CONCLUSIONS: The prevalence of PACS, PAC, and PACG in this rural population is similar to what was previously reported in urban Chinese residents. Two thirds of those with PACG were blind in at least one eye. Strategies to detect and treat this preventable disease in rural China are needed.
PURPOSE: To investigate the prevalence and characteristics of primary angle-closure suspect (PACS), primary angle closure (PAC), and primary angle-closure glaucoma (PACG) in a rural population in China. METHODS: In all, 6716 Han Chinese 30 years of age and older (5480 subjects 40 years of age and older) from 13 villages in Handan were randomly selected and completed an ophthalmologic examination, including visual acuity, intraocular pressure (IOP), slit-lamp examination, gonioscopy and stereoscopic photography, and visual field. PACS was defined as present if either eye had the posterior trabecular meshwork not visible for 180° or more on gonioscopy. PAC was present in an eye with PACS and peripheral anterior synechiae (PAS) and/or IOP ≥ 21 mm Hg, but without glaucomatous neuropathy (GON). PACG was defined as PAC with evidence of GON. RESULTS: The standardized prevalences of PACG, PAC, and PACS were 0.5% (95% confidence interval [CI]: 0.3-0.7%), 1.5% (95% CI: 1.2-1.8%), and 10.4% (95% CI: 9.6-11.2%) in those 40 years of age and older. The prevalence of all three conditions increased with age (P < 0.001). Females had much higher rates of PACS, PAC, and PACG (P < 0.05); 21 persons with PACG (65%) were blind in at least one eye: 13 were due to glaucoma and the other 8 likely had other causes. CONCLUSIONS: The prevalence of PACS, PAC, and PACG in this rural population is similar to what was previously reported in urban Chinese residents. Two thirds of those with PACG were blind in at least one eye. Strategies to detect and treat this preventable disease in rural China are needed.
Authors: Henrietta Ho; Mineo Ozaki; Takanori Mizoguchi; Shamira A Perera; Daniel H Su; Mingguang He; Tien Y Wong; Monisha E Nongpiur; Tin Aung Journal: Graefes Arch Clin Exp Ophthalmol Date: 2015-02-01 Impact factor: 3.117
Authors: Benjamin Y Xu; Michael Chiang; Shreyasi Chaudhary; Shraddha Kulkarni; Anmol A Pardeshi; Rohit Varma Journal: Am J Ophthalmol Date: 2019-08-22 Impact factor: 5.258
Authors: Benjamin Y Xu; Bruce Burkemper; Juan Pablo Lewinger; Xuejuan Jiang; Anmol A Pardeshi; Grace Richter; Mina Torres; Roberta McKean-Cowdin; Rohit Varma Journal: Ophthalmol Glaucoma Date: 2018-09-29
Authors: Benjamin Y Xu; Jacob Lifton; Bruce Burkemper; Xuejuan Jiang; Anmol A Pardeshi; Sasan Moghimi; Grace M Richter; Roberta McKean-Cowdin; Rohit Varma Journal: Am J Ophthalmol Date: 2020-07-28 Impact factor: 5.258