OBJECTIVE: To study the prevalence of fluoroquinolone-resistant Escherichia coli before transrectal ultrasound (TRUS)-guided prostate biopsy and prospectively analyze the rates of infective complications after biopsy in patients receiving fluoroquinolone prophylaxis. E. coli is the pathogen most commonly associated with infections after TRUS-guided prostate biopsy, and the prevalence of fluoroquinolone-resistant E. coli is increasing. METHODS: We analyzed the prospective data from 100 patients who underwent TRUS-guided prostate biopsy from April to December 2010. A stool culture was obtained 1 month before biopsy. Patients received 500 mg levofloxacin orally once daily for 3 days, beginning 2 hours before biopsy. All biopsies were performed as outpatient procedures. RESULTS: Of the 100 patients, 13 (13%) had a stool culture positive for fluoroquinolone-resistant E. coli. In 4 (31%) of these 13 patients, acute bacterial prostatitis was detected after TRUS-guided prostate biopsy. Of the 87 patients whose stool culture was negative for fluoroquinolone-resistant E. coli, none had acute bacterial prostatitis. All 13 infected patients were treated with carbapenems immediately after diagnosis of prostatitis and made a complete recovery. CONCLUSION: Prophylactic fluoroquinolone is still effective in preventing acute bacterial prostatitis after TRUS-guided prostate biopsy. The incidence is relatively low in patients with fluoroquinolone-sensitive E. coli. However, the prevalence of fluoroquinolone-resistant E. coli is about 13% in this population. Stool cultures for the detection of fluoroquinolone-resistant E. coli might be obtained before TRUS-guided prostate biopsy.
OBJECTIVE: To study the prevalence of fluoroquinolone-resistant Escherichia coli before transrectal ultrasound (TRUS)-guided prostate biopsy and prospectively analyze the rates of infective complications after biopsy in patients receiving fluoroquinolone prophylaxis. E. coli is the pathogen most commonly associated with infections after TRUS-guided prostate biopsy, and the prevalence of fluoroquinolone-resistant E. coli is increasing. METHODS: We analyzed the prospective data from 100 patients who underwent TRUS-guided prostate biopsy from April to December 2010. A stool culture was obtained 1 month before biopsy. Patients received 500 mg levofloxacin orally once daily for 3 days, beginning 2 hours before biopsy. All biopsies were performed as outpatient procedures. RESULTS: Of the 100 patients, 13 (13%) had a stool culture positive for fluoroquinolone-resistant E. coli. In 4 (31%) of these 13 patients, acute bacterial prostatitis was detected after TRUS-guided prostate biopsy. Of the 87 patients whose stool culture was negative for fluoroquinolone-resistant E. coli, none had acute bacterial prostatitis. All 13 infectedpatients were treated with carbapenems immediately after diagnosis of prostatitis and made a complete recovery. CONCLUSION: Prophylactic fluoroquinolone is still effective in preventing acute bacterial prostatitis after TRUS-guided prostate biopsy. The incidence is relatively low in patients with fluoroquinolone-sensitive E. coli. However, the prevalence of fluoroquinolone-resistant E. coli is about 13% in this population. Stool cultures for the detection of fluoroquinolone-resistant E. coli might be obtained before TRUS-guided prostate biopsy.
Authors: Sandro La Vignera; Rosita A Condorelli; Aldo E Calogero; Salvatore Bellanca; Mario Salmeri; Enzo Vicari Journal: Asian J Androl Date: 2012-10-15 Impact factor: 3.285
Authors: William M Mendenhall; Gabriella Glassman; Christopher G Morris; Joseph A Costa; Christopher R Williams; Stephanie E Harris; Stephen E Mandia; Bradford S Hoppe; Randal H Henderson; Curtis M Bryant; R Charles Nichols; Nancy P Mendenhall Journal: Int J Part Ther Date: 2016-08-29
Authors: Michael J Satlin; Liang Chen; Claire Douglass; Michael Hovan; Emily Davidson; Rosemary Soave; Marisa La Spina; Alexandra Gomez-Arteaga; Koen van Besien; Sebastian Mayer; Adrienne Phillips; Jing-Mei Hsu; Rianna Malherbe; Catherine B Small; Stephen G Jenkins; Lars F Westblade; Barry N Kreiswirth; Thomas J Walsh Journal: Clin Infect Dis Date: 2021-10-05 Impact factor: 20.999
Authors: Teresa R Zembower; Kelly M Maxwell; Robert B Nadler; John Cashy; Marc H Scheetz; Chao Qi; Anthony J Schaeffer Journal: BMC Infect Dis Date: 2017-06-07 Impact factor: 3.090