Literature DB >> 21903403

Antifungal activity of a series of 1,2-benzisothiazol-3(2H)-one derivatives.

Dengfeng Dou1, Deepu Alex, Bingfan Du, Kok-Chuan Tiew, Sridhar Aravapalli, Sivakoteswara Rao Mandadapu, Richard Calderone, William C Groutas.   

Abstract

A series of broad-spectrum antifungal agents based on the 1,2-benzisothiazol-3(2H)-one scaffold is reported. Preliminary structure-activity relationship studies have established the importance of the presence of the heterocyclic ring, a methyl group, and a phenyl ring for optimal manifestation of antifungal activity.
Copyright © 2011 Elsevier Ltd. All rights reserved.

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Year:  2011        PMID： 21903403     DOI： 10.1016/j.bmc.2011.08.029

Source DB:  PubMed          Journal:  Bioorg Med Chem        ISSN： 0968-0896            Impact factor:   3.641


  9 in total

1.  Evaluation of substituted ebselen derivatives as potential trypanocidal agents.

Authors:  Heeren M Gordhan; Stephen L Patrick; Maria I Swasy; Amber L Hackler; Mark Anayee; Jennifer E Golden; James C Morris; Daniel C Whitehead
Journal:  Bioorg Med Chem Lett       Date:  2016-12-10       Impact factor: 2.823

Review 2.  Antifungal drug discovery: the process and outcomes.

Authors:  Richard Calderone; Nuo Sun; Francoise Gay-Andrieu; William Groutas; Pathum Weerawarna; Sridhar Prasad; Deepu Alex; Dongmei Li
Journal:  Future Microbiol       Date:  2014       Impact factor: 3.165

3.  Inhibition of Dengue virus and West Nile virus proteases by click chemistry-derived benz[d]isothiazol-3(2H)-one derivatives.

Authors:  Kok-Chuan Tiew; Dengfeng Dou; Tadahisa Teramoto; Huiguo Lai; Kevin R Alliston; Gerald H Lushington; R Padmanabhan; William C Groutas
Journal:  Bioorg Med Chem       Date:  2011-12-30       Impact factor: 3.641

4.  Amino acid-derived 1,2-benzisothiazolinone derivatives as novel small-molecule antifungal inhibitors: identification of potential genetic targets.

Authors:  Deepu Alex; Francoise Gay-Andrieu; Jared May; Linta Thampi; Dengfeng Dou; Aileen Mooney; William Groutas; Richard Calderone
Journal:  Antimicrob Agents Chemother       Date:  2012-06-11       Impact factor: 5.191

5.  Design, synthesis and characterization of novel 1,2-benzisothiazol-3(2H)-one and 1,3,4-oxadiazole hybrid derivatives: potent inhibitors of Dengue and West Nile virus NS2B/NS3 proteases.

Authors:  Huiguo Lai; Dengfeng Dou; Sridhar Aravapalli; Tadahisa Teramoto; Gerald H Lushington; Tom M Mwania; Kevin R Alliston; David M Eichhorn; Radhakrishnan Padmanabhan; William C Groutas
Journal:  Bioorg Med Chem       Date:  2012-11-15       Impact factor: 3.641

6.  Identification of small molecule inhibitors of Jumonji AT-rich interactive domain 1B (JARID1B) histone demethylase by a sensitive high throughput screen.

Authors:  Joyce Sayegh; Jian Cao; Mike Ran Zou; Alfonso Morales; Lauren P Blair; Michael Norcia; Denton Hoyer; Alan J Tackett; Jane S Merkel; Qin Yan
Journal:  J Biol Chem       Date:  2013-02-13       Impact factor: 5.157

7.  Facile Synthesis and In Vitro Activity of N-Substituted 1,2-Benzisothiazol-3(2H)-ones against Dengue Virus NS2BNS3 Protease.

Authors:  Farwa Batool; Muhammad Saeed; Hafiza Nosheen Saleem; Luisa Kirschner; Jochen Bodem
Journal:  Pathogens       Date:  2021-04-12

8.  Synergistic effect of copolymeric resin grafted 1,2-benzisothiazol-3(2H)-one and heterocyclic groups as a marine antifouling coating.

Authors:  Miao Dong; Zheng Liu; Yuxing Gao; Xuemei Wang; Junhua Chen; Jianxin Yang
Journal:  RSC Adv       Date:  2021-05-24       Impact factor: 4.036

Review 9.  Unraveling the importance of molecules of natural origin in antifungal drug development through targeting ergosterol biosynthesis pathway.

Authors:  Fatemehsadat Jamzivar; Masoomeh Shams-Ghahfarokhi; Mansoor Khoramizadeh; Niloufar Yousefi; Mohammadhassan Gholami-Shabani; Mehdi Razzaghi-Abyaneh
Journal:  Iran J Microbiol       Date:  2019-12
  9 in total

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