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Literature DB >> 22249124

Inhibition of Dengue virus and West Nile virus proteases by click chemistry-derived benz[d]isothiazol-3(2H)-one derivatives.

Kok-Chuan Tiew¹, Dengfeng Dou, Tadahisa Teramoto, Huiguo Lai, Kevin R Alliston, Gerald H Lushington, R Padmanabhan, William C Groutas.

Abstract

Two click chemistry-derived focused libraries based on the benz[d]isothiazol-3(2H)-one scaffold were synthesized and screened against Dengue virus and West Nile virus NS2B-NS3 proteases. Several compounds (4l, 7j-n) displayed noteworthy inhibitory activity toward Dengue virus NS2B-NS3 protease in the absence and presence of added detergent. These compounds could potentially serve as a launching pad for a hit-to-lead optimization campaign.

Entities: CellLine Chemical Disease Species

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Year: 2011 PMID： 22249124 PMCID： PMC3279297 DOI： 10.1016/j.bmc.2011.12.047

Source DB: PubMed Journal: Bioorg Med Chem ISSN： 0968-0896 Impact factor: 3.641

34 in total

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2. A detergent-based assay for the detection of promiscuous inhibitors.

Authors: Brian Y Feng; Brian K Shoichet
Journal: Nat Protoc Date: 2006 Impact factor: 13.491

Review 3. The medicinal chemistry of dengue fever.

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Journal: J Med Chem Date: 2009-12-24 Impact factor: 7.446

4. Small molecule pan-dengue and West Nile virus NS3 protease inhibitors.

Authors: Lynne Cregar-Hernandez; Guan-Sheng Jiao; Alan T Johnson; Axel T Lehrer; Teri Ann S Wong; Stephen A Margosiak
Journal: Antivir Chem Chemother Date: 2011-05-12

5. On the size of the active site in proteases. I. Papain.

Authors: I Schechter; A Berger
Journal: Biochem Biophys Res Commun Date: 1967-04-20 Impact factor: 3.575

6. Modulation of the nucleoside triphosphatase/RNA helicase and 5'-RNA triphosphatase activities of Dengue virus type 2 nonstructural protein 3 (NS3) by interaction with NS5, the RNA-dependent RNA polymerase.

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Journal: J Biol Chem Date: 2005-05-24 Impact factor: 5.157

7. Homology modeling and molecular dynamics simulations of Dengue virus NS2B/NS3 protease: insight into molecular interaction.

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Review 8. Strategies for development of Dengue virus inhibitors.

Authors: Christian G Noble; Yen-Liang Chen; Hongping Dong; Feng Gu; Siew Pheng Lim; Wouter Schul; Qing-Yin Wang; Pei-Yong Shi
Journal: Antiviral Res Date: 2010-01-08 Impact factor: 5.970

9. Serotype-specific structural differences in the protease-cofactor complexes of the dengue virus family.

Authors: Sumana Chandramouli; Jeremiah S Joseph; Sophie Daudenarde; Jovylyn Gatchalian; Cromwell Cornillez-Ty; Peter Kuhn
Journal: J Virol Date: 2009-12-30 Impact factor: 5.103

10. Histone deacetylase inhibitors through click chemistry.

Authors: Jie Shen; Robert Woodward; James Patrick Kedenburg; Xianwei Liu; Min Chen; Lanyan Fang; Duxin Sun; Peng George Wang
Journal: J Med Chem Date: 2008-12-11 Impact factor: 7.446

14 in total

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Authors: Erika Piccirillo; Benjamin Merget; Christoph A Sotriffer; Antonia T do Amaral
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2. C-terminal residue optimization and fragment merging: discovery of a potent Peptide-hybrid inhibitor of dengue protease.

Authors: Mira A M Behnam; Christoph Nitsche; Sérgio M Vechi; Christian D Klein
Journal: ACS Med Chem Lett Date: 2014-07-18 Impact factor: 4.345

3. Identification of new potent inhibitors of dengue virus NS3 protease from traditional Chinese medicine database.

Authors: Vivek Dhar Dwivedi; Indra Prasad Tripathi; Shiv Bharadwaj; Aman Chandra Kaushik; Sarad Kumar Mishra
Journal: Virusdisease Date: 2016-07-20

4. Inhibitors of Dengue virus and West Nile virus proteases based on the aminobenzamide scaffold.

Authors: Sridhar Aravapalli; Huiguo Lai; Tadahisa Teramoto; Kevin R Alliston; Gerald H Lushington; Eron L Ferguson; R Padmanabhan; William C Groutas
Journal: Bioorg Med Chem Date: 2012-05-10 Impact factor: 3.641

Review 5. Targeting the protease of West Nile virus.

Authors: Saan Voss; Christoph Nitsche
Journal: RSC Med Chem Date: 2021-05-26

6. Design, synthesis and characterization of novel 1,2-benzisothiazol-3(2H)-one and 1,3,4-oxadiazole hybrid derivatives: potent inhibitors of Dengue and West Nile virus NS2B/NS3 proteases.

Authors: Huiguo Lai; Dengfeng Dou; Sridhar Aravapalli; Tadahisa Teramoto; Gerald H Lushington; Tom M Mwania; Kevin R Alliston; David M Eichhorn; Radhakrishnan Padmanabhan; William C Groutas
Journal: Bioorg Med Chem Date: 2012-11-15 Impact factor: 3.641