Literature DB >> 21899392

Correlation between serum linezolid concentration and the development of thrombocytopenia.

Yoichi Hiraki1, Yasuhiro Tsuji, Mikako Hiraike, Nobuhiro Misumi, Kana Matsumoto, Kunihiko Morita, Hidetoshi Kamimura, Yoshiharu Karube.   

Abstract

We evaluated the possible association between trough linezolid (LZD) concentrations and platelet counts using a dose-response curve with a logit model equation. We demonstrated that trough LZD concentrations correlated with platelet counts. A significant decrease in platelet count was observed in patients with trough LZD concentrations higher than 22.1 μg/ml.

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Year:  2011        PMID： 21899392     DOI： 10.3109/00365548.2011.608712

Source DB:  PubMed          Journal:  Scand J Infect Dis        ISSN： 0036-5548


  14 in total

Review 1.  Linezolid-induced thrombocytopenia in impaired renal function: is it time for a dose adjustment? A case report and review of literature.

Authors:  A P Cossu; M Musu; P Mura; L M De Giudici; G Finco
Journal:  Eur J Clin Pharmacol       Date:  2014-01       Impact factor: 2.953

2.  Risk factors for thrombocytopenia in adult chinese patients receiving linezolid therapy.

Authors:  Chao Chen; Dai-Hong Guo; Xiutang Cao; Yun Cai; Yuanjie Xu; Man Zhu; Liang Ma
Journal:  Curr Ther Res Clin Exp       Date:  2012-12

3.  Population pharmacokinetics and pharmacodynamics of linezolid-induced thrombocytopenia in hospitalized patients.

Authors:  Yasuhiro Tsuji; Nicholas H G Holford; Hidefumi Kasai; Chika Ogami; Young-A Heo; Yoshitsugu Higashi; Akiko Mizoguchi; Hideto To; Yoshihiro Yamamoto
Journal:  Br J Clin Pharmacol       Date:  2017-03-31       Impact factor: 4.335

4.  Therapeutic drug monitoring and receiver operating characteristic curve prediction may reduce the development of linezolid-associated thrombocytopenia in critically ill patients.

Authors:  H-Y Dong; J Xie; L-H Chen; T-T Wang; Y-R Zhao; Y-L Dong
Journal:  Eur J Clin Microbiol Infect Dis       Date:  2014-02-12       Impact factor: 3.267

5.  A 1 year retrospective audit of quality indicators of clinical pharmacological advice for personalized linezolid dosing: one stone for two birds?

Authors:  Federico Pea; Piergiorgio Cojutti; Lucia Dose; Massimo Baraldo
Journal:  Br J Clin Pharmacol       Date:  2015-12-05       Impact factor: 4.335

Review 6.  Dose optimisation of antibiotics in children: application of pharmacokinetics/pharmacodynamics in paediatrics.

Authors:  Kevin J Downes; Andrea Hahn; Jason Wiles; Joshua D Courter; Alexander A Vinks
Journal:  Int J Antimicrob Agents       Date:  2013-12-17       Impact factor: 5.283

Review 7.  A Review of Population Pharmacokinetic Analyses of Linezolid.

Authors:  Enrique Bandín-Vilar; Laura García-Quintanilla; Ana Castro-Balado; Irene Zarra-Ferro; Miguel González-Barcia; Manuel Campos-Toimil; Víctor Mangas-Sanjuan; Cristina Mondelo-García; Anxo Fernández-Ferreiro
Journal:  Clin Pharmacokinet       Date:  2022-06-14       Impact factor: 5.577

8.  Dosage Strategy of Linezolid According to the Trough Concentration Target and Renal Function in Chinese Critically Ill Patients.

Authors:  Fan Wu; Xiao-Shan Zhang; Ying Dai; Zi-Ye Zhou; Chun-Hong Zhang; Lu Han; Fang-Min Xu; Ye-Xuan Wang; Da-Wei Shi; Guan-Yang Lin; Xu-Ben Yu; Fang Chen
Journal:  Front Pharmacol       Date:  2022-04-11       Impact factor: 5.988

9.  Efficacy and safety of linezolid in treating gram-positive bacterial infection in the elderly: a retrospective study.

Authors:  Zhi-Yong Zhou; Xue-Qin Zhao; Bao-Zhong Shan; Jie Zhu; Xiang Zhang; Qing-Fen Tian; De-Fang Chen; Tang-Hong Jia
Journal:  Indian J Microbiol       Date:  2013-08-03       Impact factor: 2.461

Review 10.  Approach to the diagnosis and management of drug-induced immune thrombocytopenia.

Authors:  Donald M Arnold; Ishac Nazi; Theodore E Warkentin; James W Smith; Lisa J Toltl; James N George; John G Kelton
Journal:  Transfus Med Rev       Date:  2013-07-08
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