Literature DB >> 21898727

A general method for synthesis of GPI anchors illustrated by the total synthesis of the low-molecular-weight antigen from Toxoplasma gondii.

Yu-Hsuan Tsai1, Sebastian Götze, Nahid Azzouz, Heung Sik Hahm, Peter H Seeberger, Daniel Varon Silva.   

Abstract

Building blocks: a new, general synthetic strategy, which allows the construction of branched glycosylphosphatidylinositols (GPIs), enables the synthesis of parasitic glycolipid 1 from Toxoplasma gondii. In addition, the structure is further confirmed by recognition of monoclonal antibodies.
Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

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Year:  2011        PMID： 21898727     DOI： 10.1002/anie.201103483

Source DB:  PubMed          Journal:  Angew Chem Int Ed Engl        ISSN： 1433-7851            Impact factor:   15.336


  7 in total

1.  Synthetic Studies of Glycosylphosphatidylinositol (GPI) Anchors and GPI-Anchored Peptides, Glycopeptides, and Proteins.

Authors:  Zhongwu Guo
Journal:  Curr Org Synth       Date:  2013-06-01       Impact factor: 1.975

Review 2.  Recent progress in synthetic and biological studies of GPI anchors and GPI-anchored proteins.

Authors:  Shichong Yu; Zhongwu Guo; Charlie Johnson; Guofeng Gu; Qiuye Wu
Journal:  Curr Opin Chem Biol       Date:  2013-10-12       Impact factor: 8.822

Review 3.  Chemical synthesis of glycosylphosphatidylinositol anchors.

Authors:  Benjamin M Swarts; Zhongwu Guo
Journal:  Adv Carbohydr Chem Biochem       Date:  2012       Impact factor: 12.200

4.  Synthesis of biotin-labelled core glycans of GPI anchors and their application in the study of GPI interaction with pore-forming bacterial toxins.

Authors:  Jian Gao; Zhifang Zhou; Jiatong Guo; Zhongwu Guo
Journal:  Chem Commun (Camb)       Date:  2017-06-06       Impact factor: 6.222

5.  Semisynthesis of Functional Glycosylphosphatidylinositol-Anchored Proteins.

Authors:  Renée F Roller; Ankita Malik; Maria A Carillo; Monika Garg; Antonella Rella; Marie-Kristin Raulf; Bernd Lepenies; Peter H Seeberger; Daniel Varón Silva
Journal:  Angew Chem Int Ed Engl       Date:  2020-05-18       Impact factor: 15.336

6.  Detection of Anti-Toxoplasma gondii Antibodies in Human Sera Using Synthetic Glycosylphosphatidylinositol Glycans on a Bead-Based Multiplex Assay.

Authors:  Monika Garg; Daniel Stern; Uwe Groß; Peter H Seeberger; Frank Seeber; Daniel Varón Silva
Journal:  Anal Chem       Date:  2019-08-22       Impact factor: 6.986

7.  Rescue of Glycosylphosphatidylinositol-Anchored Protein Biosynthesis Using Synthetic Glycosylphosphatidylinositol Oligosaccharides.

Authors:  Paula A Guerrero; Yoshiko Murakami; Ankita Malik; Peter H Seeberger; Taroh Kinoshita; Daniel Varón Silva
Journal:  ACS Chem Biol       Date:  2021-10-07       Impact factor: 5.100
  7 in total

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