Andrew T Braun1, Christian A Merlo. 1. Division of Pulmonary and Critical Care Medicine, Johns Hopkins University, School of Medicine, Johns Hopkins Hospital, Baltimore, Maryland 21205, USA. abraun1@jhmi.edu
Abstract
PURPOSE OF REVIEW: This review summarizes recently published investigations on issues pertaining to cystic fibrosis (CF) lung transplantation. We specifically focus on indications and candidate selection as well as infectious and noninfectious issues specific to CF lung transplant recipients. RECENT FINDINGS: Recent studies have focused on candidate adequacy in high-risk CF patients. We review the current literature on individuals who develop respiratory failure requiring mechanical ventilation and those patients with a pretransplant diagnosis of pulmonary hypertension. Furthermore, the management of peri-operative infectious issues is reviewed including recurrent infections with multidrug-resistant bacterial, mycobacterial, and fungal organisms. Other CF-specific issues addressed include common comorbidities such as CF-related diabetes, gastroesophageal reflux, CF liver disease, and bone metabolism. SUMMARY: Lung transplantation is a limited, but potentially life-saving therapeutic option for patients with CF. Optimal candidate selection and awareness of CF-specific issues in the pretransplant and posttransplant setting may lead to better long-term outcomes.
PURPOSE OF REVIEW: This review summarizes recently published investigations on issues pertaining to cystic fibrosis (CF) lung transplantation. We specifically focus on indications and candidate selection as well as infectious and noninfectious issues specific to CF lung transplant recipients. RECENT FINDINGS: Recent studies have focused on candidate adequacy in high-risk CF patients. We review the current literature on individuals who develop respiratory failure requiring mechanical ventilation and those patients with a pretransplant diagnosis of pulmonary hypertension. Furthermore, the management of peri-operative infectious issues is reviewed including recurrent infections with multidrug-resistant bacterial, mycobacterial, and fungal organisms. Other CF-specific issues addressed include common comorbidities such as CF-related diabetes, gastroesophageal reflux, CF liver disease, and bone metabolism. SUMMARY: Lung transplantation is a limited, but potentially life-saving therapeutic option for patients with CF. Optimal candidate selection and awareness of CF-specific issues in the pretransplant and posttransplant setting may lead to better long-term outcomes.
Authors: Vibeke B Rudkjøbing; Trine R Thomsen; Morten Alhede; Kasper N Kragh; Per H Nielsen; Ulla R Johansen; Michael Givskov; Niels Høiby; Thomas Bjarnsholt Journal: J Clin Microbiol Date: 2011-10-19 Impact factor: 5.948
Authors: Elise J Lammertyn; Elly Vandermeulen; Hannelore Bellon; Stephanie Everaerts; Stijn E Verleden; Kathleen Van Den Eynde; Ken R Bracke; Guy G Brusselle; Pieter C Goeminne; Erik K Verbeken; Bart M Vanaudenaerde; Lieven J Dupont Journal: Respir Res Date: 2017-01-10
Authors: T O Hirche; C Knoop; H Hebestreit; D Shimmin; A Solé; J S Elborn; H Ellemunter; P Aurora; M Hogardt; T O F Wagner Journal: Pulm Med Date: 2014-03-30