Literature DB >> 21896429

[Vitamin D in the elderly: 5 points to remember].

Cédric Annweiler1, Jean-Claude Souberbielle, Anne-Marie Schott, Laure de Decker, Gilles Berrut, Olivier Beauchet.   

Abstract

Vitamin D is a secosteroid hormone. Vitamin D receptors are present in the majority of body tissues. The manifestations of hypovitaminosis D - linked to dysfunction of target tissues - are various, including osteoporosis, cancer, tuberculosis, hypertension, multiple sclerosis, depression, dementia, sarcopenia, propensity to fall… The serum 25-hydroxyvitamin D threshold value to avoid these adverse health events is around 30 ng/mL. Only 15% of the elderly reach this target concentration. For the remaining 85% with no supplements, the severity of hypovitaminosis D appears to be a biomarker of chronic diseases and of frailty. Conversely, the supplementation for correction of hypovitaminosis D positively impacts bone and non-bone morbidities - such as risks of falls and fractures - and reduces the mortality rate. A daily intake of at least 800-1,000 IU supplemental vitamin D(3) per day is the key.

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Year:  2011        PMID: 21896429     DOI: 10.1684/pnv.2011.0288

Source DB:  PubMed          Journal:  Geriatr Psychol Neuropsychiatr Vieil        ISSN: 2115-7863


  15 in total

1.  Vitamin D Insufficiency and Cognitive Function Trajectories in Older Adults: The Rancho Bernardo Study.

Authors:  Gail A Laughlin; Donna Kritz-Silverstein; Jaclyn Bergstrom; Emilie T Reas; Simerjot K Jassal; Elizabeth Barrett-Connor; Linda K McEvoy
Journal:  J Alzheimers Dis       Date:  2017       Impact factor: 4.472

Review 2.  Possibility of a new anti-alzheimer's disease pharmaceutical composition combining memantine and vitamin D.

Authors:  Cédric Annweiler; Olivier Beauchet
Journal:  Drugs Aging       Date:  2012-02-01       Impact factor: 3.923

3.  Orthostatic hypotension and vitamin D deficiency in older adults: systematic review and meta-analysis.

Authors:  Marco Zuin; Gloria Brombo; Eleonora Capatti; Tommaso Romagnoli; Giovanni Zuliani
Journal:  Aging Clin Exp Res       Date:  2021-10-10       Impact factor: 3.636

4.  Vitamin D insufficiency in the elderly orthopaedic patient: an epidemic phenomenon.

Authors:  Gerrit Steffen Maier; Konstantin Horas; Jörn Bengt Seeger; Klaus Edgar Roth; Andreas Alois Kurth; Uwe Maus
Journal:  Int Orthop       Date:  2014-09-10       Impact factor: 3.075

5.  Alzheimer's disease--input of vitamin D with mEmantine assay (AD-IDEA trial): study protocol for a randomized controlled trial.

Authors:  Cédric Annweiler; Bruno Fantino; Elsa Parot-Schinkel; Samuel Thiery; Jennifer Gautier; Olivier Beauchet
Journal:  Trials       Date:  2011-10-20       Impact factor: 2.279

6.  Age-Related Vitamin D Deficiency Is Associated with Reduced Macular Ganglion Cell Complex: A Cross-Sectional High-Definition Optical Coherence Tomography Study.

Authors:  Mathieu Uro; Olivier Beauchet; Mehdi Cherif; Alix Graffe; Dan Milea; Cedric Annweiler
Journal:  PLoS One       Date:  2015-06-19       Impact factor: 3.240

Review 7.  Neprilysin and Aβ Clearance: Impact of the APP Intracellular Domain in NEP Regulation and Implications in Alzheimer's Disease.

Authors:  Marcus O W Grimm; Janine Mett; Christoph P Stahlmann; Viola J Haupenthal; Valerie C Zimmer; Tobias Hartmann
Journal:  Front Aging Neurosci       Date:  2013-12-23       Impact factor: 5.750

Review 8.  Vitamin d in older adults: the need to specify standard values with respect to cognition.

Authors:  Cédric Annweiler; Olivier Beauchet
Journal:  Front Aging Neurosci       Date:  2014-04-15       Impact factor: 5.750

9.  Vitamin D supplements: a novel therapeutic approach for Alzheimer patients.

Authors:  Cedric Annweiler; Spyridon N Karras; Panagiotis Anagnostis; Olivier Beauchet
Journal:  Front Pharmacol       Date:  2014-01-28       Impact factor: 5.810

10.  Vitamin D and caudal primary motor cortex: a magnetic resonance spectroscopy study.

Authors:  Cedric Annweiler; Olivier Beauchet; Robert Bartha; Vladimir Hachinski; Manuel Montero-Odasso
Journal:  PLoS One       Date:  2014-01-31       Impact factor: 3.240

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