Literature DB >> 21896274

Effects of green tea catechins on gramicidin channel function and inferred changes in bilayer properties.

Helgi I Ingólfsson1, Roger E Koeppe, Olaf S Andersen.   

Abstract

Green tea's health benefits have been attributed to its major polyphenols, the catechins: (-)-epigallocatechin gallate (EGCG), (-)-epicatechin gallate (ECG), (-)-epigallocatechin (EGC), and epicatechin (EC). Catechins (especially EGCG) modulate a wide range of biologically important molecules, including many membrane proteins. Yet, little is known about their mechanism(s) of action. We tested the catechins' bilayer-modifying potency using gramicidin A (gA) channels as molecular force probes. All the catechins alter gA channel function and modify bilayer properties, with a 500-fold range in potency (EGCG>ECG≫EGC>EC). Additionally, the gallate group causes current block, as evident by brief downward current transitions (flickers).
Copyright © 2011 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

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Year:  2011        PMID： 21896274      PMCID： PMC3188397          DOI： 10.1016/j.febslet.2011.08.040

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  28 in total

Review 1.  Epigallocatechin-3-gallate (EGCG): chemical and biomedical perspectives.

Authors:  Dale G Nagle; Daneel Ferreira; Yu-Dong Zhou
Journal:  Phytochemistry       Date:  2006-07-31       Impact factor: 4.072

2.  Design and characterization of gramicidin channels.

Authors:  D V Greathouse; R E Koeppe; L L Providence; S Shobana; O S Andersen
Journal:  Methods Enzymol       Date:  1999       Impact factor: 1.600

3.  Ion channels as tools to monitor lipid bilayer-membrane protein interactions: gramicidin channels as molecular force transducers.

Authors:  O S Andersen; C Nielsen; A M Maer; J A Lundbaek; M Goulian; R E Koeppe
Journal:  Methods Enzymol       Date:  1999       Impact factor: 1.600

4.  Alcohol's effects on lipid bilayer properties.

Authors:  Helgi I Ingólfsson; Olaf S Andersen
Journal:  Biophys J       Date:  2011-08-17       Impact factor: 4.033

5.  Single GUV method reveals interaction of tea catechin (-)-epigallocatechin gallate with lipid membranes.

Authors:  Yukihiro Tamba; Shinya Ohba; Masayo Kubota; Hiroe Yoshioka; Hisashi Yoshioka; Masahito Yamazaki
Journal:  Biophys J       Date:  2007-02-09       Impact factor: 4.033

Review 6.  Molecular targets for the cancer preventive activity of tea polyphenols.

Authors:  Chung S Yang; Joshua D Lambert; Zhe Hou; Jihyeung Ju; Gang Lu; Xinpei Hao
Journal:  Mol Carcinog       Date:  2006-06       Impact factor: 4.784

Review 7.  Molecular targets of (-)-epigallocatechin-3-gallate (EGCG): specificity and interaction with membrane lipid rafts.

Authors:  S K Patra; F Rizzi; A Silva; D O Rugina; S Bettuzzi
Journal:  J Physiol Pharmacol       Date:  2008-12       Impact factor: 3.011

8.  Green tea flavonoid epigallocatechin-3-gallate (EGCG) inhibits cardiac hERG potassium channels.

Authors:  Kamilla Kelemen; Claudia Kiesecker; Edgar Zitron; Alexander Bauer; Eberhard Scholz; Ramona Bloehs; Dierk Thomas; Johannes Greten; Andrew Remppis; Wolfgang Schoels; Hugo A Katus; Christoph A Karle
Journal:  Biochem Biophys Res Commun       Date:  2007-10-09       Impact factor: 3.575

9.  The inhibitory effect of (-)-epigallocatechin gallate on activation of the epidermal growth factor receptor is associated with altered lipid order in HT29 colon cancer cells.

Authors:  Seiji Adachi; Tomokazu Nagao; Helgi I Ingolfsson; Frederick R Maxfield; Olaf S Andersen; Levy Kopelovich; I Bernard Weinstein
Journal:  Cancer Res       Date:  2007-07-01       Impact factor: 12.701

10.  Genistein can modulate channel function by a phosphorylation-independent mechanism: importance of hydrophobic mismatch and bilayer mechanics.

Authors:  Tzyh-Chang Hwang; Roger E Koeppe; Olaf S Andersen
Journal:  Biochemistry       Date:  2003-11-25       Impact factor: 3.162
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  7 in total

1.  Green tea phenolics inhibit butyrate-induced differentiation of colon cancer cells by interacting with monocarboxylate transporter 1.

Authors:  S Sánchez-Tena; P Vizán; P K Dudeja; J J Centelles; M Cascante
Journal:  Biochim Biophys Acta       Date:  2013-08-28

2.  Interactions of drugs and amphiphiles with membranes: modulation of lipid bilayer elastic properties by changes in acyl chain unsaturation and protonation.

Authors:  Michael J Bruno; Radda Rusinova; Nicholas J Gleason; Roger E Koeppe; Olaf S Andersen
Journal:  Faraday Discuss       Date:  2013       Impact factor: 4.008

3.  3,4,5-Trimethoxybenzoate of Catechin, an Anticarcinogenic Semisynthetic Catechin, Modulates the Physical Properties of Anionic Phospholipid Membranes.

Authors:  Elisa Aranda; José A Teruel; Antonio Ortiz; María Dolores Pérez-Cárceles; José N Rodríguez-López; Francisco J Aranda
Journal:  Molecules       Date:  2022-05-03       Impact factor: 4.927

4.  Phytochemicals perturb membranes and promiscuously alter protein function.

Authors:  Helgi I Ingólfsson; Pratima Thakur; Karl F Herold; E Ashley Hobart; Nicole B Ramsey; Xavier Periole; Djurre H de Jong; Martijn Zwama; Duygu Yilmaz; Katherine Hall; Thorsten Maretzky; Hugh C Hemmings; Carl Blobel; Siewert J Marrink; Armağan Koçer; Jon T Sack; Olaf S Andersen
Journal:  ACS Chem Biol       Date:  2014-06-17       Impact factor: 5.100

5.  Antidepressants are modifiers of lipid bilayer properties.

Authors:  Ruchi Kapoor; Thasin A Peyear; Roger E Koeppe; Olaf S Andersen
Journal:  J Gen Physiol       Date:  2019-02-22       Impact factor: 4.086

6.  Phosphoinositides alter lipid bilayer properties.

Authors:  Radda Rusinova; E Ashley Hobart; Roger E Koeppe; Olaf S Andersen
Journal:  J Gen Physiol       Date:  2013-06       Impact factor: 4.086

7.  Structural basis of Ca2+-dependent activation and lipid transport by a TMEM16 scramblase.

Authors:  Maria E Falzone; Jan Rheinberger; Byoung-Cheol Lee; Thasin Peyear; Linda Sasset; Ashleigh M Raczkowski; Edward T Eng; Annarita Di Lorenzo; Olaf S Andersen; Crina M Nimigean; Alessio Accardi
Journal:  Elife       Date:  2019-01-16       Impact factor: 8.140
  7 in total

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