Literature DB >> 21895304

Simultaneous in vivo imaging of melanin and lipofuscin in the retina with photoacoustic ophthalmoscopy and autofluorescence imaging.

Xiangyang Zhang, Hao F Zhang, Carmen A Puliafito, Shuliang Jiao.   

Abstract

We combined photoacoustic ophthalmoscopy (PAOM) with autofluorescence imaging for simultaneous in vivo imaging of dual molecular contrasts in the retina using a single light source. The dual molecular contrasts come from melanin and lipofuscin in the retinal pigment epithelium (RPE). Melanin and lipofuscin are two types of pigments and are believed to play opposite roles (protective versus exacerbate) in the RPE in the aging process. We have successfully imaged the retina of pigmented and albino rats at different ages. The experimental results showed that multimodal PAOM system can be a potentially powerful tool in the study of age-related degenerative retinal diseases.

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Year:  2011        PMID： 21895304      PMCID： PMC3162618          DOI： 10.1117/1.3606569

Source DB:  PubMed          Journal:  J Biomed Opt        ISSN： 1083-3668            Impact factor:   3.170


  10 in total

1.  Loss of melanin from human RPE with aging: possible role of melanin photooxidation.

Authors:  Tadeusz Sarna; Janice M Burke; Witold Korytowski; Małgorzata Rózanowska; Christine M B Skumatz; Agnieszka Zareba; Mariusz Zareba
Journal:  Exp Eye Res       Date:  2003-01       Impact factor: 3.467

2.  Age-related accumulation and spatial distribution of lipofuscin in RPE of normal subjects.

Authors:  F C Delori; D G Goger; C K Dorey
Journal:  Invest Ophthalmol Vis Sci       Date:  2001-07       Impact factor: 4.799

3.  Monitoring the accumulation of lipofuscin in aging murine eyes by fluorescence spectroscopy.

Authors:  Prasun Mukherjee; Sayantan Bose; Alyse A Hurd; Ramkrishna Adhikary; Holger Schönenbrücher; Amir N Hamir; Jürgen A Richt; Thomas A Casey; Mark A Rasmussen; Jacob W Petrich
Journal:  Photochem Photobiol       Date:  2008-08-27       Impact factor: 3.421

4.  Simultaneous dual molecular contrasts provided by the absorbed photons in photoacoustic microscopy.

Authors:  Xiangyang Zhang; Minshan Jiang; Amani A Fawzi; Xiang Li; K Kirk Shung; Carmen A Puliafito; Hao F Zhang; Shuliang Jiao
Journal:  Opt Lett       Date:  2010-12-01       Impact factor: 3.776

5.  Photoacoustic ophthalmoscopy for in vivo retinal imaging.

Authors:  Shuliang Jiao; Minshan Jiang; Jianming Hu; Amani Fawzi; Qifa Zhou; K Kirk Shung; Carmen A Puliafito; Hao F Zhang
Journal:  Opt Express       Date:  2010-02-15       Impact factor: 3.894

6.  In vivo fluorescence of the ocular fundus exhibits retinal pigment epithelium lipofuscin characteristics.

Authors:  F C Delori; C K Dorey; G Staurenghi; O Arend; D G Goger; J J Weiter
Journal:  Invest Ophthalmol Vis Sci       Date:  1995-03       Impact factor: 4.799

7.  Spectral profiling of autofluorescence associated with lipofuscin, Bruch's Membrane, and sub-RPE deposits in normal and AMD eyes.

Authors:  Alan D Marmorstein; Lihua Y Marmorstein; Hirokazu Sakaguchi; Joe G Hollyfield
Journal:  Invest Ophthalmol Vis Sci       Date:  2002-07       Impact factor: 4.799

8.  Retinal pigment epithelial lipofuscin and melanin and choroidal melanin in human eyes.

Authors:  J J Weiter; F C Delori; G L Wing; K A Fitch
Journal:  Invest Ophthalmol Vis Sci       Date:  1986-02       Impact factor: 4.799

9.  An antioxidative role of ocular screening pigments.

Authors:  M A Ostrovsky; N L Sakina; A E Dontsov
Journal:  Vision Res       Date:  1987       Impact factor: 1.886

10.  Simultaneous multimodal imaging with integrated photoacoustic microscopy and optical coherence tomography.

Authors:  Shuliang Jiao; Zhixing Xie; Hao F Zhang; Carmen A Puliafito
Journal:  Opt Lett       Date:  2009-10-01       Impact factor: 3.776
  10 in total
  27 in total

1.  Monte Carlo investigation on quantifying the retinal pigment epithelium melanin concentration by photoacoustic ophthalmoscopy.

Authors:  Xiao Shu; Wenzhong Liu; Hao F Zhang
Journal:  J Biomed Opt       Date:  2015-10       Impact factor: 3.170

2.  Photoacoustic Tomography Opening New Paradigms in Biomedical Imaging.

Authors:  Joon-Mo Yang; Cheol-Min Ghim
Journal:  Adv Exp Med Biol       Date:  2021       Impact factor: 2.622

3.  Quantifying melanin concentration in retinal pigment epithelium using broadband photoacoustic microscopy.

Authors:  Xiao Shu; Hao Li; Biqin Dong; Cheng Sun; Hao F Zhang
Journal:  Biomed Opt Express       Date:  2017-05-04       Impact factor: 3.732

4.  Visible-light optical coherence tomography-based multimodal retinal imaging for improvement of fluorescent intensity quantification.

Authors:  Zahra Nafar; Minshan Jiang; Rong Wen; Shuliang Jiao
Journal:  Biomed Opt Express       Date:  2016-08-04       Impact factor: 3.732

5.  Visible light OCT-based quantitative imaging of lipofuscin in the retinal pigment epithelium with standard reference targets.

Authors:  Zahra Nafar; Rong Wen; Shuliang Jiao
Journal:  Biomed Opt Express       Date:  2018-07-23       Impact factor: 3.732

Review 6.  Visible-light optical coherence tomography-based multimodal system for quantitative fundus autofluorescence imaging.

Authors:  Zahra Nafar; Rong Wen; Shuliang Jiao
Journal:  Exp Biol Med (Maywood)       Date:  2018-11-24

7.  Simultaneous optical coherence tomography and autofluorescence microscopy with a single light source.

Authors:  Cuixia Dai; Xiaojing Liu; Shuliang Jiao
Journal:  J Biomed Opt       Date:  2012-08       Impact factor: 3.170

8.  Integrating photoacoustic ophthalmoscopy with scanning laser ophthalmoscopy, optical coherence tomography, and fluorescein angiography for a multimodal retinal imaging platform.

Authors:  Wei Song; Qing Wei; Tan Liu; David Kuai; Janice M Burke; Shuliang Jiao; Hao F Zhang
Journal:  J Biomed Opt       Date:  2012-06       Impact factor: 3.170

9.  Integrated photoacoustic, confocal, and two-photon microscope.

Authors:  Bin Rao; Florentina Soto; Daniel Kerschensteiner; Lihong V Wang
Journal:  J Biomed Opt       Date:  2014-03       Impact factor: 3.170

10.  Systematic study of high-frequency ultrasonic transducer design for laser-scanning photoacoustic ophthalmoscopy.

Authors:  Teng Ma; Xiangyang Zhang; Chi Tat Chiu; Ruimin Chen; K Kirk Shung; Qifa Zhou; Shuliang Jiao
Journal:  J Biomed Opt       Date:  2014-01       Impact factor: 3.170
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