Literature DB >> 18764899

Monitoring the accumulation of lipofuscin in aging murine eyes by fluorescence spectroscopy.

Prasun Mukherjee1, Sayantan Bose, Alyse A Hurd, Ramkrishna Adhikary, Holger Schönenbrücher, Amir N Hamir, Jürgen A Richt, Thomas A Casey, Mark A Rasmussen, Jacob W Petrich.   

Abstract

The integrated fluorescence of murine eyes is collected as a function of age. This fluorescence is attributed to pigments generally referred to as lipofuscin and is observed to increase with age. No difference in fluorescence intensity is observed between the eyes of males or females. This work provides a benchmark for further studies that are planned in order to use such signatures as markers of central nervous system (CNS) tissue or even of diseased CNS tissue and provides a basis for determining the age of a healthy animal.

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Year:  2008        PMID: 18764899     DOI: 10.1111/j.1751-1097.2008.00425.x

Source DB:  PubMed          Journal:  Photochem Photobiol        ISSN: 0031-8655            Impact factor:   3.421


  2 in total

1.  Simultaneous in vivo imaging of melanin and lipofuscin in the retina with photoacoustic ophthalmoscopy and autofluorescence imaging.

Authors:  Xiangyang Zhang; Hao F Zhang; Carmen A Puliafito; Shuliang Jiao
Journal:  J Biomed Opt       Date:  2011-08       Impact factor: 3.170

2.  Formation of lipofuscin-like material in the RPE Cell by different components of rod outer segments.

Authors:  Lei Lei; Radouil Tzekov; J Hugh McDowell; Wesley C Smith; Shibo Tang; Shalesh Kaushal
Journal:  Exp Eye Res       Date:  2013-04-18       Impact factor: 3.467

  2 in total

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