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Literature DB >> 218914

Histochemical demonstration of mercury induced changes in rat neurons.

Abstract

A histochemical method modified for ultrastructural studies of mercury induced changes is described. Rat neurons from areas known to be influenced by mercury are used as examples. The histochemical reaction, suggested to be caused by polymercury sulphide complexes, is localized to "dense bodies" where it is visible 14 days after initiation of peroral mercury treatment (20 mg HgCl2/l drinking water).

Entities: Chemical Species

Mesh：

Year: 1979 PMID： 218914 DOI： 10.1007/bf00495724

Source DB: PubMed Journal: Histochemistry ISSN： 0301-5564

11 in total

1. Effects of the mercurial diuretic mersalyl on protein-bound sulfhydryl groups in the cytoplasm of rat kidney cells.

Authors: E J CAFRUNY; A FARAH; H S DI STEFANO
Journal: J Pharmacol Exp Ther Date: 1955-12 Impact factor: 4.030

2. Effects of mercury on lysosomal protein digestion in the kidney proximal tubule.

Authors: K M Madsen; E I Christensen
Journal: Lab Invest Date: 1978-02 Impact factor: 5.662

Review 3. The pharmacology of mercury compounds.

Authors: T W Clarkson
Journal: Annu Rev Pharmacol Date: 1972 Impact factor: 13.820

4. The intracellular distribution of mercury in rat liver after methoxyethylmercury intoxication.

Authors: T Norseth
Journal: Biochem Pharmacol Date: 1967-09-09 Impact factor: 5.858

5. The intracellular distribution of mercury in rat liver after a single injection of mercuric chloride.

Authors: T Norseth
Journal: Biochem Pharmacol Date: 1968-04 Impact factor: 5.858

6. Distribution of mercury among blood fractions and serum proteins.

Authors: H Cember; P Gallagher; A Faulkner
Journal: Am Ind Hyg Assoc J Date: 1968 May-Jun

7. Binding of mercury in the rat: studies using 203HgCl2 and gel filtration.

Authors: M Jakubowski; J Piotrowski; B Trojanowska
Journal: Toxicol Appl Pharmacol Date: 1970-05 Impact factor: 4.219

8. Ultrastructural changes in the nervous system of rabbits poisoned with methyl mercury.

Authors: J M Jacobs; N Carmichael; J B Cavanagh
Journal: Toxicol Appl Pharmacol Date: 1977-02 Impact factor: 4.219

Review 9. Heavy metals and lysosomes.

Authors: I Sternlieb; S Goldfischer
Journal: Front Biol Date: 1976

10. An improved Timm sulphide silver method for light and electron microscopic localization of heavy metals in biological tissues.

Authors: G Danscher; J Zimmer
Journal: Histochemistry Date: 1978-02-03

18 in total

1. Increased sensitivity in immunocytochemistry. Effects of double application of antibodies and of silver intensification on immunogold and peroxidase-antiperoxidase staining techniques.

Authors: L Scopsi; L I Larsson
Journal: Histochemistry Date: 1985

5. Localization of mercury in the kidney during experimental acute tubular necrosis studied by the cytochemical Silver Amplification method.

Authors: P Hultman; S Eneström
Journal: Br J Exp Pathol Date: 1986-08

10. Histochemical demonstration of heavy metals. A revised version of the sulphide silver method suitable for both light and electronmicroscopy.

Authors: G Danscher
Journal: Histochemistry Date: 1981

Histochemical demonstration of mercury induced changes in rat neurons.

1. Effects of the mercurial diuretic mersalyl on protein-bound sulfhydryl groups in the cytoplasm of rat kidney cells.

2. Effects of mercury on lysosomal protein digestion in the kidney proximal tubule.

Review 3. The pharmacology of mercury compounds.

4. The intracellular distribution of mercury in rat liver after methoxyethylmercury intoxication.

5. The intracellular distribution of mercury in rat liver after a single injection of mercuric chloride.

6. Distribution of mercury among blood fractions and serum proteins.

7. Binding of mercury in the rat: studies using 203HgCl2 and gel filtration.

8. Ultrastructural changes in the nervous system of rabbits poisoned with methyl mercury.

Review 9. Heavy metals and lysosomes.

10. An improved Timm sulphide silver method for light and electron microscopic localization of heavy metals in biological tissues.

1. Increased sensitivity in immunocytochemistry. Effects of double application of antibodies and of silver intensification on immunogold and peroxidase-antiperoxidase staining techniques.

2. Mercury-selenium interactions in relation to histochemical staining of mercury in the rat liver.

3. Simultaneous ultrastructural demonstration of heavy metals (silver, mercury) and acid phosphatase.

4. The effect of sodium chromate pretreatment on mercuric chloride-induced nephrotoxicity.

5. Localization of mercury in the kidney during experimental acute tubular necrosis studied by the cytochemical Silver Amplification method.

6. Localization of exogenous silver in brain and spinal cord of silver exposed rats.

7. The localization of mercury and metallothionein in the cerebellum of rats experimentally exposed to methylmercury.

8. Immune-mediated glomerulonephritis induced by mercuric chloride in mice.

9. The comparative toxicology of ethyl- and methylmercury.

10. Histochemical demonstration of heavy metals. A revised version of the sulphide silver method suitable for both light and electronmicroscopy.